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Results

1 970 results (0,762s) •

Result

Human enzymes involved in metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2

Carcinogenic and nephrotoxic aristolochic acids are reduced by cytochromes P450 1A1 and 1A2 to specie binding to DNA......

CE - Biochemie

  • 2001
    • •
  • Jx
Result

The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen

Reductive activation of human carcinogen (aristolochic acid I) by human cytochromes P450 1A1 and 1A2 was shown. The resulting DNA adducts reproduce the patterns found in renal tissues from humans....

CE - Biochemie

  • 2005
    • •
  • Jx
Result

Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2

Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2......

CE - Biochemie

  • 2008
    • •
  • Jx
Result

Kinetics of ellipticine oxidation by cytochromes P450 1A1 and 1A2 reconstituted with NADPH:cytochrome P450 reductase

The results demonstrate that the system of purified CYP1A1 and 1A2 reconstituted with NADPH:CYP reductase oxidizes ellipticine mainly to 9-hydroxy- and 7-hydroxyellipticine......

CE - Biochemie

  • 2007
    • •
  • Jx
Result

by cytochrome P450 1A1 and P450 1A2

Evidence for metabolic activation of 3-nitrobenzanthrone by cytochrome P450 1A1 and P450 1A2 present in human and rat liver microsomes......

CE - Biochemie

  • 2004
    • •
  • Jx
Result

Human cytochromes P450 1A1/2 and NADPH:cytochrom P450 reductase activate carcinogenic aristolochic acid to form DNA adducts found in patients with Chinese herbs nephropathy

Carcinogenic aristlochic acid causing the Chinese herbs nephropathy and carcinogenic processes is activated by microsomal cytcorhoems P450 1A1 and 1A2......

CE - Biochemie

  • 2003
    • •
  • Jx
Result

Human cytochromes P450 1A1 and 1A2 participate in detoxication of carcinogenic aristolochic acid

Human cytochromes P450 1A1 and 1A2 participate in detoxication of carcinogenic aristolochic acid...

CE - Biochemie

  • 2008
    • •
  • Jx
Result

Bioactivation versus Detoxication of the Urothelial Carcinogen Aristolochic Acid I by Human Cytochrome P450 1A1 and 1A2

by human cytochrome P450 (CYP) 1A1 and 1A2 in two CYP1A-humanized mouse lines/1a2 orthologs. Human and mouse hepatic microsomes and human CYPs were also studied. Human CYP1A1 and 1A2 were found t...

CE - Biochemie

  • 2012
    • •
  • Jx
    • •
  • Link
Result

Role of P450 1A1 and P450 1A2 in Bioactivation versus Detoxication of the Renal Carcinogen Aristolochic Acid I: Studies in Cyp1a1(-/-), Cyp1a2(-/-), and Cyp1a1/1a2(-/-) Mice

detoxication of AAI by cytochrome P450 (P450) 1A1 and 1A2 using the Cyp1a1(-/-) and Cyp1a2(-/-) single-knockout and Cyp1a1/1a2(-/-) double-knockout mouse lines. Incubations with hepatic microsome...

CE - Biochemie

  • 2011
    • •
  • Jx
    • •
  • Link
Result

Theoretical investigation of differences in nitroreduction of aristolochic acid I by cytochromes P450 1A1, 1A2 and 1B1

importance. Human cytochrome P450 (CYP) 1A1 and 1A2 enzymes were found to be responsible of the differences in mechanistic details of CYP1A1-, 1A2-, and 1B1- mediated reduct......

CE - Biochemie

  • 2012
    • •
  • Jx
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