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15 483 (0,158s) •

Result

Disruption of the dimerization interface of the sensing domain in the dimeric heme-based oxygen sensor AfGcHK abolishes bacterial signal transduction

protein is preserved via the kinase domain dimerization interface in all variants remains elusive. Here, we investigated the role of the globin domain's dimerization interface in signal transduction in AfGcHK. We ...

Biochemistry and molecular biology

  • 2019
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  • Jimp
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  • Link
Result

Cooperativity between subunits is essential for high affinity binding of N-acetylhexosamines to dimeric soluble and dimeric cellular forms of human CD69

withopening of dimer structure. However, monomeric CD69 obtained by mutating Q93 and R134 at dimer interface showed much lower affinity and no cooperativity (Hill coefficient 1.07). Perturbation of dimer inter...

CE - Biochemie

  • 2010
    • •
  • Jx
Result

Disruption of the dimerization interface of the sensing domain in the dimeric heme-based oxygen sensor AfGcHK abolishes bacterial signal transduction

dimerization interface in signal transduction in AfGcHK. We present a crystal structure protein is preserved via the kinase domain dimerization interface in all variants that the helices of the WT globin dimer...

Biochemistry and molecular biology

  • 2020
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  • Jimp
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  • Link
Result

Non-equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface

Using selective N-methylation, we systematically investigated the role of peptide bond amide hydrogens at positions B24, B25 and B26 in insulin for the dimerization ability and for the affinity of the hormone towards insulin receptor....

CC - Organická chemie

  • 2011
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  • Jx
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  • Link
Result

Human Stress-inducible Hsp70 Has a High Propensity to Form ATP-dependent Antiparallel Dimers That Are Differentially Regulated by Cochaperone Binding

dimer with the intermolecular interface closely resembling the ATP-bound dimer interfaces captured in DnaK and BiP crystal structures. ATP-dependent dimerization the ability to assemble as functionally re...

Biochemistry and molecular biology

  • 2019
    • •
  • Jimp
    • •
  • Link
Result

Human stress-inducible Hsp70 has a high propensity to form ATP dependent antiparallel dimers that are differentially regulated by cochaperone binding

dimer with the intermolecular interface closely resembling the ATP-bound dimer interfaces captured in DnaK and BiP crystal structures. ATP-dependent dimerization the ability to assemble as functionally re...

Biochemistry and molecular biology

  • 2019
    • •
  • Jimp
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  • Link
Result

Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling

signaling. Here, we show that FZD6 dimerizes and that the dimer interface of FZD6 surface receptors. They can exist and act as dimers, but the requirement of dimers the agonist-induced dissociation/re-ass...

Biochemistry and molecular biology

  • 2017
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  • Jimp
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  • Link
Result

Myristoylation drives dimerization of matrix protein from mouse mammary tumor virus

that the myristoyl groups are buried in a hydrophobic pocket at the dimer interface and contribute to dimer formation. Interestingly, the myristoyl groups in the dimer demonstrate that MA from the betaretrovirus m...

CE - Biochemie

  • 2016
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  • Jx
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  • Link
Result

Cooperation between Subunits Is Essential for High-Affinity Binding of N-Acetyl-D-hexosamines to Dimeric Soluble and Dimeric Cellular Forms of Human CD69

at the dimer interface exhibited a much lower affinity for GlcNAc (Kd=1.3 X 10-5 M to the dimeric human CD69 was followed by equilibrium dialysis, fluorescence titration) of the carbohydrate to two subunits of the dime...

CE - Biochemie

  • 2010
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  • Jx
Result

Cooperative self-assembly of dimer junctions driven by π stacking leads to conductance enhancement

We demonstrate enhanced electronic transport through dimer molecular junctions molecules assemble into dimer junctions with a per-molecule conductance that is higher that the conductance enhancement of benzimidazole dimers ...

Physical chemistry

  • 2023
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  • Jimp
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  • Link
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