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Detailed kinetic analysis of the interaction between the FOXO4-DNA-binding domain and DNA
In this work, the real-time kinetics of the interaction between the FOXO4-DNA binding domain (FOXO4-DBD) and the DNA was studied by using surface plasmon resonance suggests a structural change of FOXO4-DBD upon binding<...
BO - Biofyzika
- 2013 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 in the target site-dependent manner
to response elements (p53 DNA-binding sites), typically consisting of two copies with the antitumor drug cisplatin inhibits p53 binding to a synthetic p53 DNA-binding site. Here on binding of the...
EB - Genetika a molekulární biologie
- 2006 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
The central region of BRCA1 binds preferentially to supercoiled DNA
BRCA1 is a multifunctional tumor suppressor protein with implications in regulating processes such as cell cycle, transcription, DNA repair and chromatin remodeling with preferential binding on superhelical DNA....
BO - Biofyzika
- 2009 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Modification of DNA by new bis(aminophosphine) complexes of platinum(II) in vitro
DNA binding of two novel platinum complexes was studied by biophysical methods. DNA binding manner was different from that of cisplatin....
BO - Biofyzika
- 1998 •
- D
Rok uplatnění
D - Stať ve sborníku
Dual mode of IFI16 binding to supercoiled and linear DNA: A closer insight
expression and replication. Many IFI16-DNA binding properties were describedlength of the role of IFI16-DNA binding in distinct IFI16 functions remains unclear. Here we demon-strate two modes of IFI16 binding<...
Biochemistry and molecular biology
- 2023 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Effect of transition metals on binding of p53 protein to supercoiled DNA and to consensus sequence in DNA fragments
much weaker than the binding of the intrinsic zinc ion in the DNA binding sitsite zinc ions do not influence p53 binding to p53CON in a DNA oligonucleotide, we show that 5-20 microM zinc efficiently inhib...
FD - Onkologie a hematologie
- 1999 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
A DNA-binding copper(I) metallosupramolecular cylinder that acts as an artificial nuclease
The DNA binding of a dicationic pyridylimine-based dicopper(I) metallosupramolecular cylinder is reported together with its ability to act as an artificial nuclease. The cylinder binds strongly to DNA and shows
BO - Biofyzika
- 2006 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Selective binding of tumor suppressor p53 protein to topologically constrained DNA: Modulation by intercalative drugs
Selective binding of p53 to negatively and positively supercoiled DNA and doxorubicin as a modulators of the level of DNA supercoiling. The p53 was found to lose gradually its preferential binding to negatively scD...
BO - Biofyzika
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
DNA binding of dinuclear iron(II) metallosupramolecular cylinders. DNA unwinding and sequence preference
(with a triple helical architecture) that targets the major groove of DNA and can bind to DNA Y-shaped junctions. To explore the DNA-binding mode of [Fe2L3]4+, we examine herein the interactions of pure e...
AQ - Bezpečnost a ochrana zdraví, člověk – stroj
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
DNA topology influences p53 sequence-specific DNA binding through structural transitions within the target sites.
biochemical function is closely associated with the ability to bind DNA in a sequence investigated the effect of the DNA topology on the DNA binding of human wild type p53 supercoiling on the protein-...
EB - Genetika a molekulární biologie
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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