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Strategy of treatment in metastatic non-small cell lung cancer with driver mutations
Author presents actual informations on differences among adenocarcinomas and squamous cell carcinomas of the lung. Findings of driving mutations in tumour tissue is of value particularly in adenocarcinomas. Targeted therapy by means of tyros...
FC - Pneumologie
- 2016 •
- C
Rok uplatnění
C - Kapitola v odborné knize
Modeling cancer driver events in vitro using barrier bypass-clonal expansion assays and massively parallel sequencing
characteristics of a driver gene in that it showed a mutually exclusive mutation pattern whenThe information on candidate cancer driver alterations available from public difficulties for reliable distinction between true <...
Oncology
- 2017 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
DNA Methylation, Deamination, and Translesion Synthesis Combine to Generate Footprint Mutations in Cancer Driver Genes in B-Cell Derived Lymphomas and Other Cancers
thousands of nucleotide sequence variations. A prominent fraction of these mutations), as deduced from the analysis of the DNA sequence context of mutations in different tumor. Control experiments using shuffled weight matrices and...
Genetics and heredity (medical genetics to be 3)
- 2021 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
RAF1 gene fusions as a possible driver mechanism in rare BAP1 - inactivated melanocytic tumors: a report of 2 cases
with a BRAF-mutated melanocytic nevus and therefore are included in the group of combined nevi in the last WHO classification of skin tumors. Apart from a BRAF mutation, an NRAS mutation has been reported in rare cases, wh...
Pathology
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland
PLGAs lacking PRKD1 somatic mutations or PRKD gene family rearrangements are unlikely to harbour somatic mutations in the kinase domains of PRKD2 or PRKD3. Further studies are warranted to define the driver genetic events i...
FP - Ostatní lékařské obory
- 2016 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer
The underpinnings of STAT3 hyperphosphorylation resulting in enhanced signaling and cancer progression are incompletely understood. Loss-of-function mutations of enzymes induces STAT3 phosphorylation and cell survival, consistent witha "...
FP - Ostatní lékařské obory
- 2014 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Targeted Sequencing of Pancreatic Adenocarcinomas from Patients with Metachronous Pulmonary Metastases
Mutation spectra of 250 cancer driver, druggable, and actionable genes were gene mutation frequencies or mutational loads accounting separately for drivers. Results were complemented with the determination...
Oncology
- 2020 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Identification of novel chronic lymphocytic leukemia subtypes using pathway mutation scores and consensus clustering
a handful of putative driver genes and, more interestingly, a large number of non-recurrently mutated genes with elusive clinical implications. The aim of this study was to unravel the prognostic impact of pathway somatic mutat...
Oncology
- 2019 •
- O
Rok uplatnění
O - Ostatní výsledky
Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands
Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumor...
FP - Ostatní lékařské obory
- 2014 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
A comprehensive evaluation of pathogenic mutations in primary cutaneous melanomas, including the identification of novel loss-of-function variants
and superficial spreading melanomas identifying driver mutations using biostatistical spreading and nodular melanoma. However, the spectrum of somatic mutations developed mutations, and the newly identified TP53 l...
Oncology
- 2019 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
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