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Study of the influence of ligands and the pH of the environment on the interaction of tumor suppressor p53 with guanine quadruplexes
The aim of this project was to study p53 protein interactions with selected DNA sequences which form G-quadruplexes under suitable conditions. We studied the influence of G-quadruplex ligands and pH of the environm...
Biochemistry and molecular biology
- 2019 •
- D •
- Link
Rok uplatnění
D - Stať ve sborníku
Výsledek na webu
The Role of G-quadruplexes in Transcriptional Regulation
G-quadruplexes belong to noncanonical secondary structures of the nucleic acids the existence of G-quadruplex structures in vivo and their important regulatory roles on the transcriptional regulation by G-...
Biochemistry and molecular biology
- 2019 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Relations between the loop transposition of DNA G-quadruplex and the catalytic function of DNAzyme
The structures of DNA G-quadruplexes are essential for their functions in vivo and in vitro. Our present study revealed that sequential order of the three G-quadruplex-quadruplex conformation and consequen...
Biochemistry and molecular biology
- 2017 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
The Presence and Localization of G-Quadruplex Forming Sequences in the Domain of Bacteria
analyzed the presence and locations of G-quadruplex-forming sequences by G4Hunter in all complete bacterial genomes available in the NCBI database. G-quadruplex significantly across evolutionary groups. The highes...
Biochemistry and molecular biology
- 2019 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
The Presence and Localization of G-Quadruplex Forming Sequences in the Domain of Bacteria
analyzed the presence and locations of G-quadruplex-forming sequences by G4Hunter in all complete bacterial genomes available in the NCBI database. G-quadruplex significantly across evolutionary groups. The highes...
Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
- 2019 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
GTP-Dependent Formation of Multimeric G-Quadruplexes
G-Quadruplexes are noncanonical nucleic acid structures made up of stacked change the functional properties of G-quadruplexes, and understanding the factors of a novel mechanism by which the formation of multimeric...
Biochemistry and molecular biology
- 2019 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Multimerization rules for G-quadruplexes
G-quadruplexes can multimerize under certain conditions, but the sequence G-quadruplex to form higher-order structures. Although most of these 256 and MgCl2. As was previously shown for G-quadruplexes<...
Biochemistry and molecular biology
- 2017 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
G-QUADRUPLEXES IN p53 CANCER BIOLOGY AND AS TARGETS OF DRUGS
target gene promoters for G-quadruplex forming regions. Biophysical techniques and DMS footprinting were used for detection of G-quadruplexes in selected sequences and on drug effect on G-quadruplex
Biochemistry and molecular biology
- 2018 •
- O
Rok uplatnění
O - Ostatní výsledky
G-Quadruplexes as sensing probes
as G-quadruplexes; they are formed by the stacking of planar G-quartets composed of four guanines paired by Hoogsteen hydrogen bonding. G-quadruplexes act as ligands for metal ions and aptamers for variou...
CE - Biochemie
- 2013 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
G-quadruplexes in human telomeric region and their therapeutic potential
G-quadruplexes are types of secondary structures of nucleic acids, which are formed in guanine-rich regions. G-quadruplexes are present in promoter regions of some oncogenes and in the telomeric regions. Search fo...
ED - Fyziologie
- 2015 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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