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GATA-1 and c-myb crosstalk during red blood cell differentiation through GATA-1 binding sites in the c-myb promoter
GATA-1 and c-Myb transcription factors represent key regulators of erythroid development. GATA-1 is upregulated and c-myb protooncogene expression is downregulated of GATA-1 and c-myb expression. ...
EB - Genetika a molekulární biologie
- 2003 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
GATA-1 directly regulates p21 gene expression during erythroid differentiation.
GATA-1 directly regulates transcription of the p21 gene in both erythroleukemia cells and normal erythroid progenitors. Our findings indicate that p21 is a crucial downstream gene target and effector of GATA-1 duri...
FD - Onkologie a hematologie
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
PU.1 Activation Relieves GATA-1-Mediated Repression of Cebpa and Cbfb during Leukemia Differentiation
Manuscript describes specific mechanisms involving hematopoietic transcription factors PU.1 and GATA-1 during induced leukemia differentiation and contribute potentially to a concept for future biological " leukemia differe...
FD - Onkologie a hematologie
- 2009 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis
This review summarizes the indispensable requirement of transcription factor PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein?protein interactions with additional factors. The mu...
FD - Onkologie a hematologie
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
GATA-1 Inhibits PU.1 Gene via DNA and Histone H3K9 Methylation of Its Distal Enhancer in Erythroleukemia
GATA-1 and PU.1 are two important hematopoietic transcription factors (AML). We herein present evidence that GATA-1 binds to the PU.1 gene and inhibits its expression in human AML-erythroleukemias...
FD - Onkologie a hematologie
- 2016 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
GATA-1-mediated regulation of PU.1 gene among different erythroleukemias
GATA-1 binds to PU.1 gene regulatory regions and modulates PU.1 gene expression in human erythroleukemia cell lines OCI-M2 and K562. PU.1 gene regulation in erythroleukemia includes epigenetic changes....
EB - Genetika a molekulární biologie
- 2014 •
- A
Rok uplatnění
A - Audiovizuální tvorba
FY*A silencing by the GATA-motif variant FY*A(-69C) in a Caucasian family
The c.1-67C variant polymorphism in a GATA motif of the FY promoter is known to result in erythroid-specific FY silencing, that is, in Fy(a-) and Fy(b-) phenotypes. A Caucasian donor presented with the very rare Fy(a-b-) phenotype a...
FD - Onkologie a hematologie
- 2015 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Erythroid Transcription Factor GATA-1 Binds and Represses PU.1 Gene: Candidate Mechanism of Epigenetic Repression of PU.1 and Inefficient Erythropoiesis in MDS.
GATA-1 binds and represses PU.1 gene during early erythroid differentiation, however this is likely not fully completed in MDS and therefore erythroid differentiation is not efficient. Distribution of chromatin marks along ...
EB - Genetika a molekulární biologie
- 2013 •
- A
Rok uplatnění
A - Audiovizuální tvorba
Symmetry Breaking for GATA-1/PU.1 Model
This paper explains a substantial feature of symmetry breaking of dynamical systems that include bistability from the mathematical point of view to highlight important consequences of this phenomenon to biochemical and system biology studies since sy...
Applied mathematics
- 2019 •
- D •
- Link
Rok uplatnění
D - Stať ve sborníku
Výsledek na webu
New insights into the regulation of cytochrome P450 2C9 gene expression: the role of the transcription factor GATA-4
regulation is largely unknown. We examined the role of GATA transcription factors in the gene expression of CYP2C9. We investigated four putative GATA binding sites within construct was strongly up-regulated in Huh-7 cells co-trans...
EB - Genetika a molekulární biologie
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
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