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1 541 (0,08s) •

Result

Effects of synthetic A3 adenosine receptor agonists on cell proliferation and viability are receptor independent at micromolar concentrations

)-adenosine-5'-N- methyluronamide (IB-MECA) and 2-chloro-N6-(3-iodobenzyl)-adenosine-5?-N-methyluronamide (Cl-IB-MECA), could exert cytotoxic effects at high concentrations withor death upon treatment with micromolar concentrations ...

CE - Biochemie

  • 2013
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  • Jx
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Result

IB-MECA, an Adenosine A3 Receptor Agonist, Does Not Influence Survival of Lethally gamma-Irradiated Mice

In our previous studies, IB-MECA, an adenosine A3 receptor agonist, was found. This property of IB-MECA was considered to be responsible for its ability to support was aimed at assessing the ability of IB-MECA to influence ...

EB - Genetika a molekulární biologie

  • 2012
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  • Jx
Result

P-glycoprotein overexpression confers resistance to A3 adenosine receptor agonists 2-chloro-N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide (Cl-IB-MECA) in human leukemia cells

-MECA) the A3 adenosine receptor (A3AR) agonist has been implicated in modulation of cell proliferation and cell death. Effects of Cl-IB-MECA strongly depend on the concentrationused. Thus, nanomolar concentrations of Cl-IB-MECA...

FD - Onkologie a hematologie

  • 2008
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  • Jx
Result

P-glycoprotein mediates resistance to A3 adenosine receptor agonist 2-chloro-N6-(3-iodobenzyl)-adenosine-5?-N-methyluronamide in human leukemia cells

(Cl-IB-MECA) on apoptosis induction in the K562/Dox cell line, which overexpressed was significantlymore resistant to Cl-IB-MECA than the maternal cell line K562, which did), cytotoxic effects of Cl-IB-MECA were not preven...

ED - Fyziologie

  • 2012
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  • Jx
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Result

Occurrence of MRSA and MRS in dairy production

For monitoring the occurrence of MRSA (methicillin resistant Staphylococcus aureus) and MR-CNS (methicillin resistant coagulase-negative staphylococci) cow?s, goat?s, and sheep?s milk. Human nasal and throat swabs of the farm staff and nasal swabs of...

EE - Mikrobiologie, virologie

  • 2011
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  • O
Result

Effects of adenosine A3 receptor agonist on bone marrow granulocytic system in 5-fluorouracil-treated mice

The aim was to investigate effects of the adenosine A3 receptor agonist IB-MECA on the granulocytic system in bone marrow of mice depleted by 5-fluorouracil(5-FU). IB-MECA was injected i.p. at single doses given either once or twice...

BO - Biofyzika

  • 2006
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  • Jx
Result

The incidence of Staphylococcus bacteria with a view to MRSA in dairy production

were investigated on the ATB sensitivity. PCR method for mecA gen analysis (n=1), VA (n=1), TEC (n=2), RD (n=1), FOX (n=0). The MRSA incidence and the mecA......

EE - Mikrobiologie, virologie

  • 2009
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  • O
Result

Comparison of MRSA-Screen latex agglutination, conventional phenotypic methods and mecA gene detection for identification of oxacillin resistance in staphylococci

On the whole, 128 staphylococcal isolates frompatients of ten Czech hospitals were classified as susceptible or resistant to oxacillin by the standard broth dilution micro-method....

EC - Imunologie

  • 2002
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  • Jx
Result

Induction of apoptosis by A3 adenosine receptor agonist N6-(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide in human leukemia cells: a possible involvement of intracellular mechanism.

-methylcarboxamide (IB-MECA) was studied. Methods: To establish direct relationship between P-glycoprotein (P-gp, ABCB1, MDR1) and IB-MECA, a straightforward method for precise with micromolarconcentration of IB-MECA. Despi...

ED - Fyziologie

  • 2010
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  • Jx
Result

Occurrence and antimicrobial resistance of Staphylococcus aureus in bulk tank milk and milk filters

and mecA gene. S. aureus was detected on 25 farms (50%). The mecA gene was present in 6...

EE - Mikrobiologie, virologie

  • 2014
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