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Novel pyrazolo (4,3-D)pyrimidines, processes for their preparation and methods for therapy
The present invention is related to 3-, 5-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines represented by the general formula I and pharmaceutically acceptable salts thereof....
CE - Biochemie
- 2013 •
- P •
- Link
Rok uplatnění
P - Patent
Výsledek na webu
Pyrazolo[4,3-d]Pyrimidines
Pyrazolo[4,3-d]pyrimidines are of interest as potential kinase inhibitors on 3 afforded N-benzyl-5-chloro-3-isopropyl-1H-pyrazolo[4,3-d]pyrimidin-7-amine (6), which was further s...
CC - Organická chemie
- 2015 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors.
A search among analogues of anti-CDK purines led to the identification of substituted pyrazolo[4,3-d]pyrimidines as novel inhibitors of CDK1/cyclin B. Some of these derivatives also show antiproliferative ...
EB - Genetika a molekulární biologie
- 2003 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Novel pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy
The invention relates to 3-,5-,7-trisubstituted pyrazolo(4,3-d)pyrimidines represented by the general formula (I), and substituted alkyl, cycloalkyl etc.This invention relates to new pyrazolo(4,3-...
FD - Onkologie a hematologie
- 2010 •
- P
Rok uplatnění
P - Patent
Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use
This invention relates to new disubstituted pyrazolo[4,3-d]pyrimidine 3-, 7-trisubstituted pyrazolo[4,3-d]pyrimidines, which inhibit the cdks, cell in need of an effective amount...
CC - Organická chemie
- 2010 •
- P
Rok uplatnění
P - Patent
Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy
The invention relates to new trisubstituted pyrazolo[4,3-d]pyrimidine derivatives and to their use in suitable utilities, especially diagnostic and therapeutic of this invention to provide 3-, 5-, 7-trisubstituted ...
CC - Organická chemie
- 2010 •
- P
Rok uplatnění
P - Patent
Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy
The invention relates to new pyrazolo (4,3-d)pyrimidine derivatives, which comprises a 3,5,7-ftrisubstituted pyrazolo(4,3-d)pyrimidine heretofore. It is an object of this inventi...
CC - Organická chemie
- 2010 •
- P
Rok uplatnění
P - Patent
Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin
skeleton, we prepared 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin. Surprisingly, compound E2GG, a pyrazolo[4,3-d]pyrimidine analogue of myoseverin, display...
CE - Biochemie
- 2006 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine: Evaluation of a Novel Selective Inhibitor of Cyclin-Dependent Kinases with Antiproliferative Activity
-isopropyl-1(2)H-pyrazolo[4,3-d]pyrimidine, compound 7, was prepared as a bioisostere found in many types of human tumors. Here, a new potent CDK2 inhibitor with pyrazolo[4,3-d]pyrimi...
CE - Biochemie
- 2011 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases
pyrazolo[4,3-d]pyrimidine bioisosteres confirmed that the novel compounds are more potent in cellular assays than purines. Therefore, pyrazolo[4,3-d]pyrimidine may emer...
EB - Genetika a molekulární biologie
- 2016 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
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