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99 334 (0,226s)

Result

Radiosensitivity of DNA in a specific protein-DNA complex: the lac repressor-lac operator complex.

For specific DNA-protein complex, our calculations can predict the protein radiolytic footprints on DNA. They show the significant contribution of the protein-induced DNA conformation cha...

BO - Biofyzika

  • 2001
  • Jx
Result

Radiolysis of DNA-protein complexes

The summary of experimental measurements and theoretical predictions of radiolysis has been presented for two prokaryotic DNA- protein complexes: i)lac operator - lac repressor complex, ii) DNA bearing aba...

BO - Biofyzika

  • 2004
  • D
Result

The influence of ionizing radiation to the DNA-estrogen receptor complex

The influence of ionizing radiation on the stability of specific complex between DNA bearing estrogen response element and estrogen receptor protein. Protein irradited alone loses its ability to form the comple...

BO - Biofyzika

  • 2006
  • D
Result

Modification of DNA radiolysis by DNA-binding proteins: Structural aspects

The radiolysis of DNA-protein complexes is studied for: 1) the E. coli lactose operator-repressor complex, 2) the complex between DNA bearing an analogue of an abasic site and the repair prote...

BO - Biofyzika

  • 2007
  • Jx
Result

Effect of ionizing radiation to the specific complex of DNA with estrogen receptor protein

The stability of specific complex between DNA bearing estrogen response element and estrogen receptor protein after irradiation was determined using method of retardation polyacrylamide gel electrophoresis. Ionizing radiati...

BO - Biofyzika

  • 2005
  • D
Result

Influence of ionizing radiation to the estrogen receptor - DNA complex

Radiation damage of specific complex between DNA estrogen response element and protein estrogen receptor was studied. The overall stability of the complex and particular damages of both biomolecules under irradiati...

BG - Jaderná, atomová a molekulová fyzika, urychlovače

  • 2006
  • D
Result

Sequestering of p53 into DNA-protein filaments revealed by electron microscopy

recognition sequence (p53CON). The main structural feature of the complexes formed by either protein was a DNA-protein filament, in which two DNA duplexes are linked length and the fraction of molecules e...

BO - Biofyzika

  • 2005
  • Jx
Result

The central region of BRCA1 binds preferentially to supercoiled DNA

BRCA1 is a multifunctional tumor suppressor protein with implications in regulating processes such as cell cycle, transcription, DNA repair and chromatin remodeling with preferential binding on superhelical DNA....

BO - Biofyzika

  • 2009
  • Jx
Result

DNA radiolysis in DNA-protein complex: a stochastic simulation of attack by hydroxyl radicals.

procedure of radiolytic attack to DNA that takes into account the reactivity of each amino acid of a specifically bound protein with hydroxyl radicals. The model is applied to the natural lactose operator-repressor complex...

BO - Biofyzika

  • 2003
  • Jx
Result

Radiation damage to DNA in DNA-protein complexes

of damage of each nucleotide of DNA irradiated alone or in complexes with proteins, is responsible for the indirect effect of ionizing radiations on DNA in solution and aerobic and location of the lesions are stro...

BO - Biofyzika

  • 2011
  • Jx
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