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The SORL1 p.Y1816C variant causes impaired endosomal dimerization and autosomal dominant Alzheimer's disease
of SORLA p.Y1816C on receptor maturation, cellular localization, and trafficking in cell- based assays. Under physiological circumstances, SORLA dimerizes within the endosome, allowing retromer- dependent trafficking from ...
Other natural sciences
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
VISUALIZATION OF THE SORLA PROTEIN MUTATIONS IN THE ALZHEIMER’S DISEASE DEVELOPMENT
with the onset of AD2. SORLA protein (encoded by the SORL1 gene) functions between endosomes and the trans-Golgi network. Specifically, the SORLA protein plays with pathological SORLA mutations showing a higher incidence o...
Clinical neurology
- 2024 •
- O
Rok uplatnění
O - Ostatní výsledky
Optically transparent and electrically conductive layer consisting of a diamond layer with metallic irregular networks, a multilayer structure for a photovoltaic cell, and a photovoltaic cell
The technical realization deals with electrically conductive and optically transparent thin films commonly called as transparent conductive oxides in technology. They are used in many optoelectronic applications planar diodes, photodetectors, or ligh...
Condensed matter physics (including formerly solid state physics, supercond.)
- 2021 •
- Fuzit •
- Link
Rok uplatnění
Fuzit - Užitný vzor
Výsledek na webu
Visualizing the effects of SORLA mutation in Alzheimer’s disease progression
Aim: investigate whether pathogenic mutation Y1816C in SORL1 leads to altered APP processing and enlarged endosomes in human 2D neurons and 3D organoids in vitro....
Clinical neurology
- 2024 •
- O
Rok uplatnění
O - Ostatní výsledky
Stem Cell Plasticity and Issues of Stem Cell Therapy
Critical evaluation of relationship of stem cell plasticity and the questions of stem cells plasticity and the questions of stem cell therapy....
FD - Onkologie a hematologie
- 2005 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
The reduction of the cell nuclear size in the cell body space during the differentiation might be cell lineage specific (a retrospective morphological note)
The cell body space occupied by the nucleus decreased during the cell differentiation of the granulocytic cell lineage in CML (Chronic Myeloid Leukemia) patients. In contrary, in patients suffering from CLL (Chronic Lymphoc...
Hematology
- 2023 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Filter unit for separating cells from blood samples
The present device is a filter unit that has been developed for cell separation based on different cell sizes. The device can be used to filter cell suspensions such as tumor cells or blood cells from dilu...
Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)
- 2019 •
- Gfunk
Rok uplatnění
Gfunk - Funkční vzorek
Method for separation of sperm with undamaged intact heads from sperm with damaged heads and somatic cells
and from sperm with damaged heads and / or somatic cells and / or cell debris in a cell sample obtained from a human body, comprising the steps of: 1. contacting the cell the CD46-presenting cells and / o...
Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)
- 2021 •
- P •
- Link
Rok uplatnění
P - Patent
Výsledek na webu
Method for separation of sperm with undamaged intact heads from sperm with damaged heads and somatic cells
and from sperm with damaged heads and / or somatic cells and / or cell debris in a cell sample obtained from a human body, comprising the steps of: 1. contacting the cell the CD46-presenting cells and / o...
Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)
- 2021 •
- P •
- Link
Rok uplatnění
P - Patent
Výsledek na webu
Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture
Cell cycle represents not only a tightly orchestrated mechanism of cell replication and cell division but it also plays an important role in regulation of cell fate decision. Particularly in the context of pluripot...
EB - Genetika a molekulární biologie
- 2013 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
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