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Therapy of small cell lung cancer with emphasis on oral topotecan
Systemic chemotherapy plays a major role in the management of patients with small cell lung cancer. In the second-line setting, topotecan showed similar efficacy but better tolerability compared to combination chemotherapy and similar effica...
FC - Pneumologie
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Topotecan in the treatment of advanced recurrent epithelial ovarian cancer
We observed good results with topotecan treatment as second-line chemotherapy in patients with advanced recurrent ovarian cancer. Results are so encouraging that warrants further investigation as first-line agent....
FD - Onkologie a hematologie
- 2000 •
- D
Rok uplatnění
D - Stať ve sborníku
Topotecan vitreous and plasma levels and retinal toxicity after transcorneal intravitreal delivery in healthy albino rabbits: Alternative retinoblastoma treatment
after transcorneal intravitreal injection of 1 mu g and 2 mu g of topotecan injection of 1 mu g (group A) or 2 mu g (group B) of topotecan. Vitreous and blood of saline. Plasma and vitreous levels of topotecan were determi...
FP - Ostatní lékařské obory
- 2012 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
The role of cryotherapy in vitreous concentrations of topotecan delivered by episcleral hydrogel implant
. In this in vivo study, the delivery of topotecan via lens-shaped, bi-layered hydrogel implants to higher concentrations of topotecan in the vitreous. The study included 18 New Zealand albino rabbits. Nine rabbits received a to...
Polymer science
- 2022 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Antiproliferative effects of selected chemotherapeutics in human ovarian cancer cell line A2780
cisplatin, paclitaxel, carboplatin, gemcitabine, topotecan and etoposide with paclitaxel and topotecan.
FD - Onkologie a hematologie
- 2012 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
2-Hydroxyethyl methacrylate hydrogels for local drug delivery: study of topotecan and vincristine sorption/desorption kinetics and polymer-drug interaction by ATR-FTIR spectroscopy
on the sorption capacity and mechanism of the release of topotecan (TPT) and vincristine (VCR...
Polymer science
- 2021 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Hydrogel implants for transscleral diffusion delivery of topotecan: in vivo proof of concept in a rabbit eye model
bi-layered hydrogel implant for delivery of topotecan (TPT) via transscleral...
Polymer science
- 2021 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
A sensitive bioanalytical ultra-high-performance liquid chromatography-tandem mass spectrometry method for the simultaneous quantitation of lactone and carboxylate forms of topotecan in plasma
Topotecan (TPT) is used in the treatment of retinoblastoma, the most common malignant intraocular tumor in children. TPT undergoes pH-dependent hydrolysis of the lactone ring to the ring-opened carboxylate form, with the lactone form showing...
Polymer science
- 2024 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Resistance/sensitivity in vitro in ovarian cancer patients
The highest frequency of resistance in vitro occured for etoposid, gemcitabin and paclitaxel and the most effective chemotherapeutical agents were cisplatinum and topotecan. Cisplatin had the lowest incidence of drug resistance in vitro than...
FK - Gynekologie a porodnictví
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Hydrogel implants for transscleral drug delivery for retinoblastoma treatment
therapeutically active doses of low molecular weight hydrophilic antitumor drugs topotecan topotecan-loaded and a minimum of 6 days for vincristine-loaded hydrogels). The bi......
Polymer science
- 2019 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
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