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Combined Approach to Leukemic Differentiation Using Transcription Factor PU.1-Enhancing Agents
The transcription factor PU.1 (Purine-rich DNA binding, SPI1) is a key). The degree of transcriptional regulation of the PU.1 gene is influenced by repression via to progenitor maturation...
Hematology
- 2022 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis
This review summarizes the indispensable requirement of transcription factor PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein?protein interact...
FD - Onkologie a hematologie
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development
The transcription factor PU.1 recruits c-Jun as a co-activator to promoters without AP-1 binding sites, and mice with point mutations in PU.1 that disrupts the interaction between PU1 and...
Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
- 2022 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
5-Azacitidine in aggressive myelodysplastic syndromes regulates chromatin structure at PU.1 gene and cell differentiation capacity
understood, approach. Hematopoietic transcription factor PU.1 is dynamically regulated by upstream regulatory element (URE), whose deletion causes downregulation of PU.1 leading, as well as MDS c...
FD - Onkologie a hematologie
- 2012 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
PU.1 Activation Relieves GATA-1-Mediated Repression of Cebpa and Cbfb during Leukemia Differentiation
Manuscript describes specific mechanisms involving hematopoietic transcription factors PU.1 and GATA-1 during induced leukemia differentiation and contribute potentially to a concept for future biological ...
FD - Onkologie a hematologie
- 2009 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
GATA-1 Inhibits PU.1 Gene via DNA and Histone H3K9 Methylation of Its Distal Enhancer in Erythroleukemia
GATA-1 and PU.1 are two important hematopoietic transcription factors or myeloid lineage, respectively. PU.1 controls its own expression during myelopoiesis (AML). We herein present evide...
FD - Onkologie a hematologie
- 2016 •
- Jx •
- Link
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Erythroid Transcription Factor GATA-1 Binds and Represses PU.1 Gene: Candidate Mechanism of Epigenetic Repression of PU.1 and Inefficient Erythropoiesis in MDS.
GATA-1 binds and represses PU.1 gene during early erythroid differentiation, however this is likely not fully completed in MDS and therefore erythroid differentiation is not efficient. Distribution of chromatin marks along ...
EB - Genetika a molekulární biologie
- 2013 •
- A
Rok uplatnění
A - Audiovizuální tvorba
5-azacytidine in aggressive myelodysplastic syndromes regulates chromatin structure at PU.1 gene and cell differentiation capacity
understood, approach. Hematopoietic transcription factor PU.1 is dynamically regulated by upstream regulatory element (URE), whose deletion causes downregulation of PU.1 leading, as well as MDS c...
EB - Genetika a molekulární biologie
- 2012 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
SWI/SNF Blockade Disrupts PU.1-Directed Enhancer Programs in Normal Hematopoietic Cells and Acute Myeloid Leukemia
the hematopoietic transcription factor PU.1 (SPI1) as an important target of SWI/SNF inhibition, but PU.1 is widely regarded to have pioneer-like activity. As a result, many questions have remain...
Organic chemistry
- 2023 •
- Jimp •
- Link
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Expression profiles of certain transcription factors in osteoclast differentiation
by similar transcription factors as other blood cell types. Differentiation of osteclasts is usually induced by combination of cytokines M-CSF (CSF-1) and RANKL. This work is focused on expression profiles of transcrip...
EB - Genetika a molekulární biologie
- 2008 •
- D
Rok uplatnění
D - Stať ve sborníku
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