Deregulation of Gene Expression Induced by Environmental Tobacco Smoke Exposure in Pregnancy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8210" target="_blank" >RIV/00064203:_____/12:8210 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/12:00382957 RIV/00216208:11130/12:8210 RIV/00023736:_____/12:00010113

Výsledek na webu

<a href="http://dx.doi.org/10.1093/ntr/ntr325" target="_blank" >http://dx.doi.org/10.1093/ntr/ntr325</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Deregulation of Gene Expression Induced by Environmental Tobacco Smoke Exposure in Pregnancy

Popis výsledku v původním jazyce

Environmental tobacco smoke (ETS) exposure in pregnant women may have detrimental effects such as spontaneous abortion, lower birth weight, stillbirth, and reduced infant lung function. To extend our knowledge on the molecular effects of tobacco smoke exposure in pregnancy, we analyzed transcriptome alterations in passive smokers (PS) and compared them with those in active smokers (AS). Using Illumina Expression Beadchips with 24,526 transcript probes, gene expression patterns were assayed in placentasfrom PS (N = 25) exposed to ETS throughout pregnancy and nonexposed (NS) counterparts (N = 34) and in cord blood cells from their newborns. ETS exposure was evaluated by questionnaire disclosure and cotinine measurement in maternal and cord blood. A total of 158 genes were significantly deregulated in the placentas of PS compared with NS. These genes were associated with the extracellular matrix, apoptosis, placental function, blood clotting, response to stress, and lipid metabolism. Cor

Název v anglickém jazyce

Deregulation of Gene Expression Induced by Environmental Tobacco Smoke Exposure in Pregnancy

Popis výsledku anglicky

Environmental tobacco smoke (ETS) exposure in pregnant women may have detrimental effects such as spontaneous abortion, lower birth weight, stillbirth, and reduced infant lung function. To extend our knowledge on the molecular effects of tobacco smoke exposure in pregnancy, we analyzed transcriptome alterations in passive smokers (PS) and compared them with those in active smokers (AS). Using Illumina Expression Beadchips with 24,526 transcript probes, gene expression patterns were assayed in placentasfrom PS (N = 25) exposed to ETS throughout pregnancy and nonexposed (NS) counterparts (N = 34) and in cord blood cells from their newborns. ETS exposure was evaluated by questionnaire disclosure and cotinine measurement in maternal and cord blood. A total of 158 genes were significantly deregulated in the placentas of PS compared with NS. These genes were associated with the extracellular matrix, apoptosis, placental function, blood clotting, response to stress, and lipid metabolism. Cor

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FQ - Veřejné zdravotnictví, sociální lékařství

OECD FORD obor

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Projekt

<a href="/cs/project/2B06088" target="_blank" >2B06088: Využití toxikogenomiky při studiu mechanismů působení cizorodých látek v životním prostředí na lidské zdraví.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nicotine & Tobacco Research

ISSN

1462-2203

e-ISSN

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Svazek periodika

14

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

1073-1082

Kód UT WoS článku

000308545800010

EID výsledku v databázi Scopus

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