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7E13061

PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

  • Call for proposals

    7E13061-2013

  • Main participants

    Fakultní nemocnice Brno

  • Contest type

    RP - Co-financing of EC programme

  • Contract ID

    MSMT-42111/2013

Alternative language

  • Project name in Czech

    PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood

  • Annotation in Czech

    Survival rates after childhood cancer now reach nearly 80% in developed European countries as a result of more effective therapies and better supportive care, leading to a steady increase in the number of survivors in the population. However, the treatments that have improved survival are harsh and cause serious side-effects that can greatly impact survivors’ quality of life in the long term. The goal of PanCareLIFE is that survivors of cancer diagnosed before age 25 should enjoy the same quality of life and opportunities as their peers who have not had cancer. Using observational studies and molecular genetic investigations PanCareLIFE will investigate late effects that impact fertility and hearing impairment (ototoxicity), and will assess health-related quality of life. Information from PanCareLIFE’s studies will be incorporated into new guidelines for fertility preservation. As the number of survivors with late effects in any one country is small, large cohorts are required for accurate estimation of risk. PanCareLIFE has assembled a team of prominent investigators from 8 European countries who will contribute in total over 12,000 well-characterised research subjects to identify risk factors, both genetic and non-genetic, linked to decrements in fertility and ototoxicity. Quality-of-life studies will evaluate the impact of fertility and ototoxicity. PanCareLIFE will advance the state-of-the-art in survivorship studies by evaluation of large cohorts with observational and genetic tools that will provide better knowledge of individual risk factors. Survivors can then be stratified into groups benefitting from personalized, evidence-based, care; future patients may expect effective therapies to have less severe side effects, and plans for a seamless transition to long-term follow-up care can be made. These approaches will result in better quality of life for survivors of cancer diagnosed at a young age.

Scientific branches

  • R&D category

    AP - Applied research

  • CEP classification - main branch

    FD - Oncology and haematology

  • CEP - secondary branch

    FK - Gynaecology and obstetrics

  • CEP - another secondary branch

    FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    30204 - Oncology<br>30205 - Hematology<br>30206 - Otorhinolaryngology<br>30207 - Ophthalmology<br>30208 - Dentistry, oral surgery and medicine<br>30214 - Obstetrics and gynaecology

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider.

Solution timeline

  • Realization period - beginning

    Nov 1, 2013

  • Realization period - end

    Oct 31, 2018

  • Project status

    U - Finished project

  • Latest support payment

    Feb 14, 2018

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP19-MSM-7E-U/01:1

  • Data delivery date

    Jun 18, 2019

Finance

  • Total approved costs

    1,596 thou. CZK

  • Public financial support

    1,596 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK