Mutations of ryanodine receptor in relationship to malignant arrhythmias and sudden cardiac death in patients with heart failure
Project goals
The aim of the project is to contribute to better understanding of sudden cardiac death pathophysiology. The study population will consist of high risk patients with heart failure who survived malignant ventricular arrhythmia. In these individuals occurence of RyR2 gene polymorphisms will be investigated compared to a control group to assess the role of RyR2 in arrhythmogenesis. Working hypothesis is based on fact that in catecholaminergic polymorphic ventricular tachycardia a significant number of asymptomatic RyR2 mutation carriers have been found. Such a latent mutation will reveal only under stress conditions - in heart failure - and it will contribute to malignant arrhythmia and sudden death.
Keywords
arrhythmiageneheart failureion channelmutationryanodine receptorRyR2sudden death
Public support
Provider
Ministry of Education, Youth and Sports
Programme
Health and quality of life
Call for proposals
Zdravý a kvalitní život 2 (SMSM20082B2)
Main participants
—
Contest type
VS - Public tender
Contract ID
1182/2010-31
Alternative language
Project name in Czech
Mutace ryanodinového receptoru ve vztahu k maligním arytmiím a náhlé srdeční smrti u pacientů se srdečním selháním
Annotation in Czech
Cílem projektu je zjistit výskyt polymorfizmů genu RyR2 u vysoce rizikové skupiny pacientů s chronickým srdečním selháním, kteří přežili nahromadění maligních komorových arytmií ? tzv. arytmickou bouři - tedy přežili NSS
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
FA - Cardiovascular diseases including cardio-surgery
CEP - secondary branch
EB - Genetics and molecular biology
CEP - another secondary branch
—
10603 - Genetics and heredity (medical genetics to be 3)
10604 - Reproductive biology (medical aspects to be 3)
10605 - Developmental biology
10608 - Biochemistry and molecular biology
10609 - Biochemical research methods
30101 - Human genetics
30201 - Cardiac and Cardiovascular systems
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
The research was realized according to the schedule. The expected results have been probably achieved
Solution timeline
Realization period - beginning
Mar 1, 2008
Realization period - end
Dec 31, 2011
Project status
U - Finished project
Latest support payment
Feb 25, 2011
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP12-MSM-2B-U/01:1
Data delivery date
Jul 3, 2012
Finance
Total approved costs
7,594 thou. CZK
Public financial support
6,651 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
943 thou. CZK
Basic information
Recognised costs
7 594 CZK thou.
Public support
6 651 CZK thou.
87%
Provider
Ministry of Education, Youth and Sports
CEP
FA - Cardiovascular diseases including cardio-surgery
Solution period
01. 03. 2008 - 31. 12. 2011