BIOactive highly porous and injectable Scaffolds controlling stem cell recruitment, proliferation and differentiation and enabling angiogenesis for Cardiovascular ENgineered Tissues
Public support
Provider
Ministry of Education, Youth and Sports
Programme
—
Call for proposals
FP7-NMP-2007-LARGE-1
Main participants
—
Contest type
RP - Co-financing of EC programme
Contract ID
1088/2011-321
Alternative language
Project name in Czech
BIOactive highly porous and injectable Scaffolds controlling stem cell recruitment, proliferation and differentiation and enabling angiogenesis for Cardiovascular ENgineered Tissues
Annotation in Czech
Congenital and acquired diseases of the heart are the leading causes of morbidity and mortality in the world today; 7.2 million people die each year due to coronary heart disease, being the first cause of mortality in population above 60 years old, and the second cause after HIV in world wide young population. There is an urgent demand for new methods to repair and replace damaged cardiovascular tissues. One of the most promising ways to achieve this goal is the development of regenerative therapies aided with novel intelligent nanobiomaterials such as bioactive scaffolds. The overall objective of this project is the development of innovative bioactive polymeric scaffolds able to guide tissue formation from dissociated stem cells, for engineering autologous cardiovascular replacements, namely vascular tissues, heart valves and cardiac muscle. Two different strategies will be followed to approach creating new engineered tissue: 1.In vitro tissue engineering: according to the most frequent tissue engineering paradigm, cells will be seeded on a scaffold composed of synthetic polymer or natural material and the tissue will be matured in vitro in a bioreactor, in order to obtain a construct that can be implanted in the appropriate anatomic location as a prosthesis; 2.In vivo tissue engineering: unseeded scaffolds that attract endogenous cells and control cell proliferation and differentiation will be implanted to repopulate and remodel an altered cardiovascular tissue. The strong innovative content of the project is in the realisation of multifunctional scaffolds which can guide complex cellular processes such as adhesion, proliferation and differentiation, processes fundamental for tissue regeneration. It is therefore necessary to design integrated material scaffolds and culture environments, which can appropriately confer biochemical, morphological, electrical and mechanical stimuli to a developing tissue.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
BO - Biophysics
CEP - secondary branch
FA - Cardiovascular diseases including cardio-surgery
CEP - another secondary branch
EB - Genetics and molecular biology
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>10610 - Biophysics<br>30101 - Human genetics<br>30201 - Cardiac and Cardiovascular systems
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider.
Solution timeline
Realization period - beginning
Jan 1, 2009
Realization period - end
Dec 31, 2013
Project status
U - Finished project
Latest support payment
Feb 28, 2013
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP14-MSM-7E-U/01:1
Data delivery date
Jun 30, 2014
Finance
Total approved costs
1,244 thou. CZK
Public financial support
1,244 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK