Natural inorganic polymers and smart functionalized micro-units applied in customized rapid prototyping of bioactive scaffolds
Public support
Provider
Ministry of Education, Youth and Sports
Programme
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Call for proposals
FP7-NMP-2013-EU-China
Main participants
Vysoké učení technické v Brně / Středoevropský technologický institut
Contest type
RP - Co-financing of EC programme
Contract ID
MSMT-42111/2013
Alternative language
Project name in Czech
Natural inorganic polymers and smart functionalized micro-units applied in customized rapid prototyping of bioactive scaffolds
Annotation in Czech
The application of rapid prototyping techniques has become a new trend in the fabrication of customized scaffolds for tissue regeneration or repair. The aim of the proposed project is to provide novel solutions for bottle-neck problems currently faced inestablishing the corresponding processing chain, which encounter, among others, the extraction of essential geometry data of the damaged tissue from medical images, e.g. CT and MRI, with a resolution sufficient enough to guide CAD/CAM- based materials manufacturing processes; the establishment of a feasible interfaces between medical imaging, CAD and CAM; and the fabrication, by rapid prototyping techniques, i.e. selective laser sintering, 3D printing and robocasting, of customized scaffolds based on an innovative morphogenetically active bio-inorganic polymer, bio-silica, either alone or in combination with another bio-inorganic polymer, bio-polyP, as well as smart micro-units. Customization of both external geometry and internal cellular architecture, and of the material properties of the scaffolds will be achieved. The main focus is the development of novel osteogenic scaffolds which obviate the need of exogenously added growth factors/cytokines in bone tissue engineering. The scaffolds made of the bioactive bio-inorganic polymers or their composites with traditional bio- ceramics will fulfil both mechanical and physiological requirements for the intended biomedical applications. In addition, this project will provide a new strategy for 3D printing of bone-forming cells by exploiting the unique advantages of cell- encapsulating bio-silica alginate hydrogels. The multidisciplinary consortium proposing this project comprises internationally top-ranked researchers in Europe and in China and includes an already established Joint Lab between European and Chinese partners providing the necessary infrastructure and competence to realize a fast integration and a proof-of-concept within the proposed 3-year funding period.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
JH - Ceramics, fire-proof materials and glass
CEP - secondary branch
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CEP - another secondary branch
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OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
20504 - Ceramics
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider.
Solution timeline
Realization period - beginning
Jan 1, 2014
Realization period - end
May 31, 2016
Project status
U - Finished project
Latest support payment
Feb 26, 2016
Data delivery to CEP
Confidentiality
C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.
Data delivery code
CEP17-MSM-7E-U/01:1
Data delivery date
Jun 20, 2017
Finance
Total approved costs
2,145 thou. CZK
Public financial support
2,145 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK