Metrology for drug delivery
Public support
Provider
Ministry of Education, Youth and Sports
Programme
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Call for proposals
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Main participants
Český metrologický institut
Contest type
M2 - International cooperation
Contract ID
8B19002
Alternative language
Project name in Czech
Metrology for drug delivery
Annotation in Czech
The overall objective of this project is to enable traceable measurements of the volume, flow rate and pressure of existing drug delivery devices (and other medical devices, like infusion pump analysers and organ-on-a-chip) and in-line sensors that work at a flow rate lower than 100 nL/min. This project will also investigate fast changing flow rates, liquid mixing behaviour and occlusion phenomena in multi-infusion systems in order to improve the dosing accuracy in each infusion line. The specific objectives of the project are: 1. To develop new traceable techniques for generating and measuring the response or delay time of drug delivery devices regarding changes in flow rate, from 5 nL/min to 100 nL/min, using Newtonian liquids (WP1). For steady flow rates an uncertainty of 1 % (k=2) or better is expected, whereas for fast changing flow rates an uncertainty of 2 % (k=2) or better is expected. The techniques developed will be used to characterise and validate the different response times of at least 3 different types of drug delivery devices (including infusion analysers) (WP3 and WP4) and one type of flow sensor, to accurately measure the administered flow and volume with the required uncertainties. 2. To upgrade the existing flow facilities and knowledge of the partner NMIs in order to enable the traceable in-line measurement of the dynamic viscosity of Newtonian liquids, as a function of the flow rate and pressure difference, with a target uncertainty value of 2 % (k=2). The measurement uncertainty will be validated using Newtonian liquids with traceable dynamic viscosity calibration. Additionally, tests with non-Newtonian liquids will be performed in order to prove the concept. To calibrate transfer standards for the in-line measurement of dynamic viscosity and other physical EMPIR
Scientific branches
R&D category
AP - Applied research
OECD FORD - main branch
10700 - Other natural sciences
OECD FORD - secondary branch
10700 - Other natural sciences
OECD FORD - another secondary branch
10700 - Other natural sciences
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
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Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider.
Solution timeline
Realization period - beginning
Jun 1, 2019
Realization period - end
May 31, 2022
Project status
U - Finished project
Latest support payment
Feb 21, 2022
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP23-MSM-8B-U
Data delivery date
Jun 30, 2023
Finance
Total approved costs
2,823 thou. CZK
Public financial support
2,823 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK