Cancer Genomics of the Kidney

Provider

Ministry of Education, Youth and Sports

Programme

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Call for proposals

FP7-Health-2009-two-stage

Main participants

—

Contest type

RP - Co-financing of EC programme

Contract ID

MSMT-1839/2013-310

Project name in Czech

Cancer Genomics of the Kidney

Annotation in Czech

The International Cancer Genome Consortium (ICGC) has the goal of obtaining a comprehensive description of genomic, transcriptomic and epigenomic changes in 50 different tumour types and/or subtypes, with the aim of elucidating the genomic changes present in the many forms of cancers that contribute to the burden of disease throughout the world. Here, we present a proposal for a European contribution to this effort through application of state-of-the-art approaches to the genomic analysis of clear cellrenal carcinoma. This cancer is of particular interest within Europe, as the highest global incidence rates are observed in areas of Central Europe. Kidney cancer incidence has increased over the last two decades, and it is now the 8th most common cancerin the EU. CAGEKID brings clinical and epidemiological resources together with the necessary genetics and genomics expertise across Europe required for this effort. In the first phase of the study, 50 matched pairs of DNA extracted from the tumour and constitutional DNA will be completely sequenced, and brought together with information from whole genome transcript analysis and DNA methylation analysis from tumoural and peritumoural tissue. In the second phase, 450 additional sample pairs will be analysed in a targeted manner. The results from this part of the study will be used to relay the acquired information to targeted protein analyses. The primary data will be made available to the scientific community, and the programme will contribute to establishing norms for the manipulation and protein analyses. The primary data will be made available to the scientific community, and the programme will contribute to establishing norms for the manipulation and storage of biological samples. CAGEKID will provide the first systematic analysis of this tumour site , and it will give new insights into disease aetiology with application for diagnosis and treatment.

R&D category

AP - Applied research

CEP classification - main branch

FD - Oncology and haematology

CEP - secondary branch

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CEP - another secondary branch

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OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

30204 - Oncology<br>30205 - Hematology

Provider evaluation

U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

Project results evaluation

Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider.

Realization period - beginning

Jan 1, 2011

Realization period - end

Feb 28, 2014

Project status

U - Finished project

Latest support payment

Mar 20, 2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data delivery code

CEP15-MSM-7E-U/01:1

Data delivery date

Jul 2, 2015

Total approved costs

1,215 thou. CZK

Public financial support

1,215 thou. CZK

Other public sources

0 thou. CZK

Non public and foreign sources

0 thou. CZK