Phosphorylation-mediated signalling in DNA damage response and cancer
Public support
Provider
Ministry of Education, Youth and Sports
Programme
EEA/Norwegian Financial Mechanism
Call for proposals
Finanční mechanismy EHP/Norsko 1 (SMSM20147F1)
Main participants
Ústav molekulární genetiky AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
MSMT/28477/2014
Alternative language
Project name in Czech
Phosphorylation-mediated signalling in DNA damage response and cancer
Annotation in Czech
In this application we will investigate the following five aims: Aim I) Molecular mechanism of PPM1D/Wip1 phosphatase function in DDR Aim II) Role of truncating PPM1D mutations in colorectal cancer Aim III) Functional role of PP1 phosphatase in DNA damage checkpoints and repair Aim IV) Novel role of ATR-Chk1-Aurora-A signalling in Fanconi anemia pathway Aim V) Molecular mechanism of Cdc7 kinase-dependent replisome stabilization
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
FD - Oncology and haematology
CEP - secondary branch
—
CEP - another secondary branch
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OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
30204 - Oncology<br>30205 - Hematology
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
The PHOSCAN project may be deemed to be executed. In addition to above described, researchers found that cancer cells that carry genetic changes in studied pathways are more sensitive to chemotherapy whereas others do not respond well to the treatment. Finding of such a caliber will contribute to better prediction of therapeutic response and design targeted cancer treatment. Scientific quality of all participating teams and their international recognition is high. Consortium achieved several clinically relevant observations published in high level scientific journals. Overall project rating is therefore outstanding.
Solution timeline
Realization period - beginning
Aug 7, 2014
Realization period - end
Apr 30, 2017
Project status
U - Finished project
Latest support payment
Mar 15, 2017
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP18-MSM-7F-U/05:1
Data delivery date
Nov 21, 2018
Finance
Total approved costs
25,520 thou. CZK
Public financial support
25,520 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK