Phosphine Ligands for Environmentally Friendly C-C Bond Forming Reactions
Public support
Provider
Ministry of Education, Youth and Sports
Programme
EEA/Norwegian Financial Mechanism
Call for proposals
Finanční mechanismy EHP/Norsko 1 (SMSM20147F1)
Main participants
Univerzita Karlova / Přírodovědecká fakulta
Contest type
VS - Public tender
Contract ID
MSMT-23681/2015-2
Alternative language
Project name in Czech
Phosphine Ligands for Environmentally Friendly C-C Bond Forming Reactions
Annotation in Czech
This grant project aims at minimizing the negative environmental impact of Suzuki-Miyaura reaction as a prominent representative of practically important transition metal-catalyzed process through improving the ligand design. It is based on our previous work by which we have demonstrated that even a typically hydrophobic ligand can be made highly hydrophilic by introduction of charged amidosulfonate pendants. Within this project we would like to build upon this synthetic approach through its modifications and applications to other prominent ligand scaffolds that have been already recognized as catalytically privileged structures. The syntheses and catalytic tests will be performed with support from extensive physicochemical measurements and theoretical computations in order to gain an insight into the nature of factors determining catalytic properties and to base the design of the particular catalyst component upon rational grounds. In other words, the key objectives of this grant projects is the design, preparation and catalytic evaluation of new efficient ligands for Suzuki-Miyaura reaction performed in water and water/organic solvent biphase systems that could make this reaction less environmentally demanding. The design will be based on the combination of conventional variation approach (synthetic structure modification) and in silico studies.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
CA - Inorganic chemistry
CEP - secondary branch
CC - Organic chemistry
CEP - another secondary branch
—
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10401 - Organic chemistry<br>10402 - Inorganic and nuclear chemistry
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
This ENVIPHOS project was based on sharing expertise of the participating teams which was accomplished. The project promoter benefited mostly from the implementation of new theoretical approaches, while the Norwegian partner advantageously utilized the results and ideas of the project promoter in improving their computational approach toward ligand design. Both teams brought very good scientific results and publication. The overall project rating is very good.
Solution timeline
Realization period - beginning
Jul 13, 2015
Realization period - end
Apr 20, 2017
Project status
U - Finished project
Latest support payment
Apr 10, 2017
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP18-MSM-7F-U/05:1
Data delivery date
Nov 21, 2018
Finance
Total approved costs
13,316 thou. CZK
Public financial support
11,280 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
2,036 thou. CZK