Metrology for clinical implementation of dosimetry in molecular radiotherapy
Public support
Provider
Ministry of Education, Youth and Sports
Programme
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Call for proposals
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Main participants
Český metrologický institut
Contest type
M2 - International cooperation
Contract ID
MSMT-21096/2016-7
Alternative language
Project name in Czech
Metrology for clinical implementation of dosimetry in molecular radiotherapy
Annotation in Czech
The specific objectives of this project are: 1. To determine branching ratios and emission probabilities for 90Y and 166Ho in order to enable improved quantitative imaging (QI) accuracy and dose estimation for these radionuclides, and to exploit new technologies in order to develop a suitable transfer instrument optimised for accuracy of measurements of the activity of MRT agents in clinics and radiopharmaceutical companies. 2. To develop 3D printing methods in order to generate a range of quasi-realistic anthropomorphic phantoms containing compartments fillable with known activities of radioactive liquid or standardised sealed radioactive test sources, having a range of geometrical complexity for validation of multimodal EMPIR Page 7 of 48 15HLT06 RTDosimetry Annex 1 v1.0 QI or absorbed dose measurement, and estimation of the uncertainties of measurement. In addition, to expand the protocol developed in JRP HLT11 for traceable calibration of SPECT QI for 177Lu activity to include PET-CT QI of 90Y and SPECT QI of 131I, validated by measurements using the quasi-realistic anthropomorphic 3D printed phantoms. 3. To generate multimodal images either from SPECT or PET-CT phantom measurements or Monte Carlo (MC) simulations to provide material for an open-access database of reference images to be used as reference data for commissioning and Quality Control (QC) of QI using SPECT or PET-CT. In addition, to develop an architecture for and host the open-access database.
Scientific branches
R&D category
VV - Exeperimental development
CEP classification - main branch
FD - Oncology and haematology
CEP - secondary branch
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CEP - another secondary branch
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OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
30204 - Oncology<br>30205 - Hematology
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider.
Solution timeline
Realization period - beginning
Jun 1, 2016
Realization period - end
May 31, 2019
Project status
U - Finished project
Latest support payment
Feb 12, 2019
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP20-MSM-8B-U/01:1
Data delivery date
Jun 18, 2020
Finance
Total approved costs
7,992 thou. CZK
Public financial support
4,188 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
3,802 thou. CZK