Novel peptide‐based aggregation inhibitors as potential therapeutics for neurodegenerative diseases

Provider
Ministry of Education, Youth and Sports
Programme
Programme for Funding Multilateral Scientific and Technological Cooperation Projects in the Danube Region
Call for proposals
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Main participants
Masarykova univerzita / Přírodovědecká fakulta
Contest type
M2 - International cooperation
Contract ID
-

Project name in Czech
Novel peptide‐based aggregation inhibitors as potential therapeutics for neurodegenerative diseases
Annotation in Czech
The project's overall objective is to identify LEA-based proteins/peptides with Aβ40 and α-Syn antiaggregation potential to promote the development of novel strategies for the treatment of AD and PD. The project's specific objectives are: (i) Structural characterization of the selected 4 LEAPs with potential to inhibit α-Syn and Aβ40 aggregation. (ii)Defining the Aβ40/LEAPs and α-Syn/LEAPs interactions. (iii) Identification of LEAPs/Aβ40 and LEAP/α-Syn binding interface and design of LEA-based peptides (iv) Assessment of the toxicity and overall effects of selected LEA-based peptides in neural cell lines. (v) Validation of Aβ40 and α-Syn anti-aggregation potential of LEA-based peptides in vitro, in neural cells and in C. elegans.

R&D category
ZV - Basic research
OECD FORD - main branch
10610 - Biophysics
OECD FORD - secondary branch
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OECD FORD - another secondary branch
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CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
BO - Biophysics

Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP25-MSM-8X-R
Data delivery date
Aug 6, 2025

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