Exploring the impact of somatic expansion rates on quantitative progression marker candidates (Voice) in early stages of Repeat Expansion Disorders

Provider

Ministry of Education, Youth and Sports

Programme

—

Call for proposals

—

Main participants

České vysoké učení technické v Praze / Fakulta elektrotechnická

Contest type

M2 - International cooperation

Contract ID

MSMT-4300/2024-42/2

Project name in Czech

Exploring the impact of somatic expansion rates on quantitative progression marker candidates (Voice) in early stages of Repeat Expansion Disorders

Annotation in Czech

Aim 1: Identify and characterize molecularly a population of patients carrying repeat expansion mutations at early disease stages/prodromal (within 5 years to predicted onset) by determining the length of the uninterrupted triplet repeat stretch, and somatic expansion index and somatic expansion rate Aim 2: Study longitudinally the bespoken, informative population using quantitative progression marker candidates and somatic expansion rate Aim 3: Analyze the correlation of change rates (somatic expansions and quantitative traits)

R&D category

VV - Exeperimental development

OECD FORD - main branch

30210 - Clinical neurology

OECD FORD - secondary branch

—

OECD FORD - another secondary branch

—

CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

FH - Neurology, neuro-surgery, nuero-sciences

Realization period - beginning

Sep 1, 2025

Realization period - end

Aug 30, 2028

Project status

Z - Beginning multi-year project

Latest support payment

—

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data delivery code

CEP25-MSM-9F-R

Data delivery date

Mar 20, 2025

Total approved costs

6,206 thou. CZK

Public financial support

6,206 thou. CZK

Other public sources

0 thou. CZK

Non public and foreign sources

0 thou. CZK