Advanced Carriers for Platinum Drugs
Project goals
Novel advanced carriers for platinum drugs and prodrugs will be developed in this project. The carriers will be based on macrocyclic cavitands, molecular capsules, and biocompatible polymers. The drug-carrier systems will be chemically and structurally characterized mainly by using NMR spectroscopy as a primary tool for analyzing supramolecular assemblies. pH dependent activation of prodrugs and carriers as well as photoactivation of Pt(IV) complexes will be investigated experimentally and modeled using relativistic DFT methods. Biological activity of developed systems will be studied on selected human cancer cell lines.
Keywords
Drug deliverycisplatinoxaliplatincancer treatmentprodrugmetallodrugcavitandmolecular capsuledrug-polymer conjugateNMR-spectroscopyrelativistic-DFTtransition-metal complexbindingreductionactivation
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
Standardní projekty 20 (SGA0201600001)
Main participants
Masarykova univerzita / Středoevropský technologický institut
Contest type
VS - Public tender
Contract ID
16-05961S
Alternative language
Project name in Czech
Pokročilé nosiče platinových léčiv
Annotation in Czech
V rámci projektu budou vyvinuty nové pokročilé nosiče platinových léčiv a proléčiv. Nosiče budou založeny na makrocyklických kavitandech, molekulárních schránkách a biokompatibilních polymerech. Systémy léčivo-nosič budou chemicky a strukturně charakterizovány především pomocí NMR spektroskopie jako primárního nástroje pro analýzu supramolekulárních útvarů. pH závislá aktivace proléčiv a nosičů a fotoaktivace Pt(IV) komplexů bude zkoumána experimentálně a modelována pomocí relativistických DFT metod. Biologická aktivita vyvinutých systémů bude studována na vybraných lidských nádorových liniích.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
CA - Inorganic chemistry
CEP - secondary branch
CC - Organic chemistry
CEP - another secondary branch
CF - Physical chemistry and theoretical chemistry
10401 - Organic chemistry
10402 - Inorganic and nuclear chemistry
10403 - Physical chemistry
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
In project, Pt complexes (Pt2+ as potential drugs and Pt4+ as their prodrugs) were synthesized and modified polysaccharides were prepared as their carriers. Supramolecular interactions of synthesized compounds with cyclodextrins and cucurbutrils were investigated. NMR parameters for nuclei of heavy metal elements (involving platinum) in their complexes were measured and theoretically calculated.
Solution timeline
Realization period - beginning
Jan 1, 2016
Realization period - end
Jul 22, 2020
Project status
U - Finished project
Latest support payment
May 25, 2018
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP21-GA0-GA-U/06:1
Data delivery date
Jun 30, 2021
Finance
Total approved costs
9,763 thou. CZK
Public financial support
9,763 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK
Basic information
Recognised costs
9 763 CZK thou.
Public support
9 763 CZK thou.
100%
Provider
Czech Science Foundation
CEP
CA - Inorganic chemistry
Solution period
01. 01. 2016 - 22. 07. 2020