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Chiral bambusurils

Project goals

Design and synthesis of chiral supramolecular hosts are of great interest because these molecules could be used for determination of enantiomeric excess or for enantiomer separation. Bambusurils are macrocycles praised for their high affinity towards anions. However, only achiral bambusurils have been investigated up today. In this project we propose several synthetic approaches for the synthesis of chiral bambusurils. Ability of these macrocycles to discriminate or distinguish one enantiomer form the other will be investigated by means of NMR and UV-Vis spectroscopy and isothermal titration calorimetry.

Keywords

supramolecular chemistrymacrocyclesbambusurils,anion receptorsenantiomers

Public support

  • Provider

    Czech Science Foundation

  • Programme

    Standard projects

  • Call for proposals

    Standardní projekty 22 (SGA0201800001)

  • Main participants

    Masarykova univerzita / Přírodovědecká fakulta

  • Contest type

    VS - Public tender

  • Contract ID

    18-21801S

Alternative language

  • Project name in Czech

    Chirální bambusurily

  • Annotation in Czech

    Velká pozornost je v současnosti věnována návrhu a syntéze chirálních supramolekulárních hostitelských molekul, protože tyto molekuly mohou být použity pro stanovení enantiomerního přebytku nebo pro separaci enantiomerů. Bambusurily jsou makrocykly, které jsou ceněny pro svou vysokou afinitu k aniontům. Nicméně do dnešní doby byly studovány pouze achirální bambusurily. V tomto projektu navrhujeme několik syntetických postupů vedoucích k chirálním bambusurilům. Bude studována schopnost těchto makrocyklů rozdělit nebo rozlišit jeden enantiomer od druhého s pomocí NMR a UV-Vis spektroskopie a izotermální titrační kalorimetrie.

Scientific branches

  • R&D category

    ZV - Basic research

  • OECD FORD - main branch

    10401 - Organic chemistry

  • OECD FORD - secondary branch

    —

  • OECD FORD - another secondary branch

    —

  • CC - Organic chemistry

Solution timeline

  • Realization period - beginning

    Jan 1, 2018

  • Realization period - end

    Dec 31, 2020

  • Project status

    —

  • Latest support payment

    Apr 24, 2020

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP21-GA0-GA-R/10:1

  • Data delivery date

    Feb 22, 2021

Finance

  • Total approved costs

    4,553 thou. CZK

  • Public financial support

    4,263 thou. CZK

  • Other public sources

    326 thou. CZK

  • Non public and foreign sources

    0 thou. CZK

Basic information

Recognised costs

4 553 CZK thou.

Public support

4 263 CZK thou.

93%

Provider

Czech Science Foundation

OECD FORD

Organic chemistry

Solution period

01. 01. 2018 - 31. 12. 2020

Similar projects(10)

Monofunctionalized bambusurils and their supramolecular properties (GA20-13922S) Synthesis and supramolecular properties of bambusurils (GA13-15576S) New chiral composite magnetic membranes combined with rotational and magnetic levitation forces for racemic mixture separation (GA25-15195S)