RAD60 - a new player in the maintenance of genome stability in plants
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Ústav experimentální botaniky AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
26-20390S
Alternative language
Project name in Czech
RAD60 - a new player in the maintenance of genome stability in plants
Annotation in Czech
Genome stability is maintained via a network of DNA damage response (DDR) proteins orchestrated by specific signal molecules and post-translational modifications. The attachment of a Small Ubiquitin-like Modifier (SUMO) protein to the target proteins is essential for DDR signaling. Here, we propose a project focusing on the functional characterization of a newly discovered plant homolog of the RENi family protein RAD60. RENi proteins contain tandemly organized SUMO-like domains and, in conjunction with interacting proteins, stimulate SUMOylation during DDR. Interestingly, plant RAD60 has only a single SUMO-like domain and a unique N-terminus. In this project, we will cooperatively (i) anchor the Arabidopsis RAD60 in the plant DDR pathways, (ii) study its role in preventing genome instability, (iii) identify its interaction partners, and (iv) characterize its stimulatory effect on SUMOylation of plant DDR factors. The results of this project will greatly improve the functional understanding of the role of SUMOylation in the plant DDR.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10611 - Plant sciences, botany
OECD FORD - secondary branch
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OECD FORD - another secondary branch
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CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
EF - Botany
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
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Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
Jun 1, 2026
Finance
Total approved costs
13,103 thou. CZK
Public financial support
13,103 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK