Pulmonary Hypertension: A Multitarget Approach Using Tailored Galectin Inhibitors
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Mikrobiologický ústav AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
26-20451S
Alternative language
Project name in Czech
Pulmonary Hypertension: A Multitarget Approach Using Tailored Galectin Inhibitors
Annotation in Czech
Galectins are soluble human lectins with many (patho)physiological effects. Galectin-1, -3, -8 and -9 have been implicated in the pathogenesis of cardiovascular diseases such as pulmonary hypertension (PH). The common manifestation of the different subtypes of this heterogeneous disease is pulmonary vascular remodeling. The pathways of galectin action in the development and progression of PH are poorly defined. We intend to evaluate the therapeutic potential and pharmacokinetics of newly prepared tailored glycopolymer galectin inhibitors with proven inhibitory potential to galectins in a series of in vitro and in vivo assays. In vitro studies with pulmonary artery endothelial cells, smooth muscle cells, adventitial and cardiac fibroblasts will complement in vivo assays with rat models of hypoxia- and monocrotaline-induced PH. We aim to elucidate the mechanisms of PH pathophysiology related to individual galectins and to assess the potential of their pharmacological inhibition as a novel therapeutic strategy for PH.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10608 - Biochemistry and molecular biology
OECD FORD - secondary branch
30104 - Pharmacology and pharmacy
OECD FORD - another secondary branch
30203 - Respiratory systems
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
CE - Biochemistry<br>EB - Genetics and molecular biology<br>FC - Pneumology<br>FR - Pharmacology and apothecary chemistry
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
May 19, 2026
Finance
Total approved costs
12,290 thou. CZK
Public financial support
11,918 thou. CZK
Other public sources
372 thou. CZK
Non public and foreign sources
0 thou. CZK