Do pollutants with thyroid receptor antagonistic activity increase the susceptibility of fish and amphibians to pathogens?

Provider

Czech Science Foundation

Programme

Standard projects

Call for proposals

SGA0202600001

Main participants

Jihočeská univerzita v Českých Budějovicích / Fakulta rybářství a ochrany vod

Contest type

VS - Public tender

Contract ID

26-20993S

Project name in Czech

Do pollutants with thyroid receptor antagonistic activity increase the susceptibility of fish and amphibians to pathogens?

Annotation in Czech

Some endocrine disruptors interfere with the hypothalamus-pituitary-thyroid axis in vertebrates. Thyroid receptor (TR) blockade, mainly of TRβ, is one of the well-documented modes of action of thyroid disrupting chemicals. This activity has already been documented in the aquatic environment. As the thyroid controls several immune pathways, it is hypothesised that thyroid disrupting chemicals may also affect the immune response of fish and amphibians living in polluted areas. As a result, animals with an impaired immune response may be more susceptible to pathogens normally found in the aquatic environment. Both fish and amphibians are considered to be among the most endangered groups of animals. It is therefore necessary to search for environmental factors that cause their decline. In the proposed project, model fish and amphibian species will be exposed to substances with anti-thyroid activity during early development, when their thyroid and immune systems are forming. The immune response and susceptibility of the animals to selected pathogens will be studied.

R&D category

ZV - Basic research

OECD FORD - main branch

10511 - Environmental sciences (social aspects to be 5.7)

OECD FORD - secondary branch

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OECD FORD - another secondary branch

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CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

DI - Pollution and air control<br>DJ - Pollution and water control<br>DK - Contamination and decontamination of soil including pesticides<br>DL - Nuclear waste, radioactive pollution and control<br>DM - Solid waste and its control, recycling<br>DO - Protection of landscape

Realization period - beginning

Jan 1, 2026

Realization period - end

Dec 31, 2028

Project status

Z - Beginning multi-year project

Latest support payment

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Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data delivery code

CEP26-GA0-GA-R

Data delivery date

Apr 29, 2026

Total approved costs

9,995 thou. CZK

Public financial support

9,926 thou. CZK

Other public sources

69 thou. CZK

Non public and foreign sources

0 thou. CZK