Nanofibers with Shish-Kebab Topography Enabling Reduced Antimicrobial Use with High Efficiency
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Technická univerzita v Liberci / Fakulta přírodovědně-humanitní a pedagogická
Contest type
VS - Public tender
Contract ID
26-21103S
Alternative language
Project name in Czech
Nanofibers with Shish-Kebab Topography Enabling Reduced Antimicrobial Use with High Efficiency
Annotation in Czech
Infections resulting from injuries can lead to severe, potentially fatal outcomes, making their prevention a critical challenge in modern healthcare. To prevent infections, wound dressings are often functionalized with antibiotics or antimicrobial agents. However, the overuse of such agents has accelerated the emergence of multidrug-resistant bacteria. Hence, the target of this project proposal is to develop a new type of superstructure PCL nanofibers with unique nanotopography serving as drug carriers of one (NFSK-SDC) or two (NFSK-DDC) antimicrobial agents. These will combine their bactericidal effects based on both mechanical (e.g., nanopillar puncture) and chemical influences, using lower but effective amounts of antimicrobials, thereby preventing drug overuse. This approach is based on a hypothesis that (i) by combining morphological effects, such as fiber diameter, and especially nanotopography, pathogens' ability of adhesion and colonization of the material by microbes may be decreased, and (ii) the required antimicrobial load in the material can be reduced.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10606 - Microbiology
OECD FORD - secondary branch
21001 - Nano-materials (production and properties)
OECD FORD - another secondary branch
30404 - Biomaterials (as related to medical implants, devices, sensors)
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
EE - Microbiology, virology<br>EI - Biotechnology and bionics<br>JJ - Other materials
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
Jun 26, 2026
Finance
Total approved costs
12,086 thou. CZK
Public financial support
10,916 thou. CZK
Other public sources
976 thou. CZK
Non public and foreign sources
194 thou. CZK