Mapping tumor-associated macrophage-T cell interplay in ovarian carcinoma: implications for immunotherapy
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Mikrobiologický ústav AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
26-21317S
Alternative language
Project name in Czech
Mapping tumor-associated macrophage-T cell interplay in ovarian carcinoma: implications for immunotherapy
Annotation in Czech
Although immune checkpoint inhibition (ICI) by PD-1 blockade has revolutionized immunotherapy, it benefits only in a subset of patients. Non-small cell lung carcinoma (NSCLC) is typically ICI-responsive, immunologically hot, and enriched in tertiary lymphoid structures (TLS) and stem-like CD8+ T cells, whereas high-grade serous ovarian carcinoma (HGSOC) is generally the opposite. Based on our preliminary data, we hypothesize that immunosuppressive tumor-associated macrophages (TAMs) inhibit T-cell responses to ICI therapy. To test this, we will investigate the mechanisms of TAM-mediated ICI-resistance in human HGSOC and NSCLC samples, as well as unique murine models of HGSOC using a multidisciplinary approach. In parallel, we will assess whether targeting IFN/STAT1 signaling, inhibiting PTPN1/2 phosphatases, and/or promoting IL-2 signaling can overcome ICI resistance in HGSOC. This project will improve our understanding of immunosuppressive mechanisms in the tumor microenvironment and identify novel strategies to increase the efficacy of cancer immunotherapy.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
30102 - Immunology
OECD FORD - secondary branch
10601 - Cell biology
OECD FORD - another secondary branch
30204 - Oncology
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
EA - Morphology and cytology<br>EC - Immunology<br>FD - Oncology and haematology
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
Jun 15, 2026
Finance
Total approved costs
12,960 thou. CZK
Public financial support
12,813 thou. CZK
Other public sources
147 thou. CZK
Non public and foreign sources
0 thou. CZK