Wiskott-Aldrich Syndrome Protein in Lymphomagenesis: Unraveling the Interplay Between Somatic Mutations, B-cell Receptor Signaling and Actin Dynamics
Public support
Provider
Czech Science Foundation
Programme
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Call for proposals
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Main participants
Univerzita Karlova / 1. lékařská fakulta
Contest type
M2 - International cooperation
Contract ID
26-22366K
Alternative language
Project name in Czech
Wiskott-Aldrich Syndrome Protein in Lymphomagenesis: Unraveling the Interplay Between Somatic Mutations, B-cell Receptor Signaling and Actin Dynamics
Annotation in Czech
Non-Hodgkin lymphomas (NHL) are the 5th to 9th most frequently diagnosed cancer word wide. The most frequent NHL type is diffuse large B-cell lymphoma (DLBCL) which has specifically defined genetic subtypes. One of them, the so called EZB DLBCL, is affected by somatic mutations of genes coding for proteins involved in the homeostasis of germinal center B cells (EZH2, GNA12, GNA13, S1PR2, ARHGEF1, RHOA). Based on the literature and preliminary data, we believe that these alterations affect the cortical actin dynamics and related B-cell receptor (BCR) signaling via modulation of the Wiskott-Aldrich syndrome protein (WASp) function. We propose that this phenomenon represents a potential therapeutic target and that WASp has additional lymphoma important nuclear function. These associations were not investigated before, therefore, we believe that our studies will bring important new information related to critical aspects of lymphomagenesis, and molecular mechanisms in general, as well as new therapeutic targets for patients with hematological cancers and with autoimmune disorders.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
30204 - Oncology
OECD FORD - secondary branch
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OECD FORD - another secondary branch
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CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
FD - Oncology and haematology
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
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Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GF-R
Data delivery date
May 23, 2026
Finance
Total approved costs
11,292 thou. CZK
Public financial support
11,292 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK