Metabolomics-driven discovery of plant chemical novelty and its insecticidal potential
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Ústav organické chemie a biochemie AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
26-21882S
Alternative language
Project name in Czech
Metabolomics-driven discovery of plant chemical novelty and its insecticidal potential
Annotation in Czech
In this proposal, we will develop an integrative pipeline for high-throughput discovery of structurally novel natural products from plants and assess their insecticidal potential against polyphagous insects. We will combine phylogenomics and automated literature mining to prioritize and select understudied plant lineages for phytochemical investigation. We will profile the metabolite content of the selected plant species using mass spectrometry-based metabolomics, and analyze the resulting data using state-of-the-art computational tools. Using a cheminformatics approach recently developed in our lab, we will select 50 plant extracts with the highest structural novelty potential and screen them for insecticidal activity against a panel of 5 polyphagous insect species. This screening will: i) lead to the discovery of structurally-novel phytochemicals with insecticidal potential; ii) generate a large dataset of plant-insect interactions linked to their chemical profiles. This data will constitute a valuable resource for other disciplines (e.g., entomology, chemical ecology).
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10611 - Plant sciences, botany
OECD FORD - secondary branch
10619 - Biodiversity conservation
OECD FORD - another secondary branch
10609 - Biochemical research methods
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
CE - Biochemistry<br>EB - Genetics and molecular biology<br>EF - Botany<br>EH - Ecology - communities
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
Apr 30, 2026
Finance
Total approved costs
8,659 thou. CZK
Public financial support
8,014 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
645 thou. CZK