A neurobiological model of paraphilic development in the male rat
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Národní ústav duševního zdraví
Contest type
VS - Public tender
Contract ID
26-22378S
Alternative language
Project name in Czech
A neurobiological model of paraphilic development in the male rat
Annotation in Czech
Theories of the development of paraphilias in humans posit predisposing genetic and/or personality traits, and/or early sexual experience with paraphilic behaviors that are predictive of sexual arousal and/or orgasm. It is impossible to know conclusively what type or amount of experience during early sexual development leads to paraphilic interests, and what kind of brain activation sustains those interests into adulthood. The proposed studies will examine the development of paraphilic-like preferences for neutral or aversive odors, or neutral somatosensory stimuli that are paired with orgasm-like responses in male rats. We have shown that the opioid receptor antagonist naloxone and the lysine-specific demethylase inhibitor oryzin can block conditioning, indicating that opioid-induced epigenetic changes are important for its development. We will extend these findings to examine common brain regions activated by the conditioned stimuli, and within those regions, to examine demethylated and methylated states of genes with either excitatory or inhibitory actions on sexual behavior.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
30301 - Social biomedical sciences (includes family planning, sexual health, psycho-oncology, political and social effects of biomedical research)
OECD FORD - secondary branch
30103 - Neurosciences (including psychophysiology)
OECD FORD - another secondary branch
30403 - Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
EI - Biotechnology and bionics<br>FH - Neurology, neuro-surgery, nuero-sciences<br>FL - Psychiatry, sexology
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
May 19, 2026
Finance
Total approved costs
13,010 thou. CZK
Public financial support
13,010 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK