Unraveling the Regulatory Landscape of Neuronal T-Type Calcium Channel Variants in Human Disease
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Univerzita Karlova / 3. lékařská fakulta
Contest type
VS - Public tender
Contract ID
26-23565S
Alternative language
Project name in Czech
Unraveling the Regulatory Landscape of Neuronal T-Type Calcium Channel Variants in Human Disease
Annotation in Czech
T-type calcium channels play a vital role in neuronal excitability, hormone secretion, and development. Genetic variations in these channels are associated with disorders such as epilepsy, autism spectrum disorders, and schizophrenia. However, current functional analyses often rely on recombinant systems that fail to fully capture the complex regulatory mechanisms influencing these channels. This project aims to provide a comprehensive assessment of T-type channel variants under physiologically relevant conditions, incorporating factors such as the cellular environment, regulatory proteins, physiological temperature, and alternative splicing. By refining our understanding of how these variants behave in native contexts, we aim to uncover their precise roles in disease and identify new avenues for therapeutic intervention.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10608 - Biochemistry and molecular biology
OECD FORD - secondary branch
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OECD FORD - another secondary branch
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CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
CE - Biochemistry<br>EB - Genetics and molecular biology
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
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Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
Apr 27, 2026
Finance
Total approved costs
8,262 thou. CZK
Public financial support
8,262 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK