On the Trail of the Tubulin Code: Exploring Ciliopathy Mechanisms and Therapeutic Opportunities
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Ústav molekulární genetiky AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
26-21078S
Alternative language
Project name in Czech
On the Trail of the Tubulin Code: Exploring Ciliopathy Mechanisms and Therapeutic Opportunities
Annotation in Czech
Ciliopathies are a group of disorders characterized by dysfunctional cilia, small sensory membrane protrusions found on nearly all human cells. Bardet-Biedl Syndrome (BBS) is a rare multisystemic ciliopathy caused by malfunction of a ciliary cargo adaptor BBSome. Despite significant therapeutic progress, the syndromic nature and unclear etiopathology of BBS pose challenges to developing new treatments. Within the proposed project, we aim to investigate the functional dependencies between the Ciliary Transport Machineries, BBSome, and KIF14, and the Tubulin Code in healthy and BBS condition. Subsequently, we will investigate the strategies to mitigate the BBS symptoms, such as the cilia-targeted tubulin modifying enzymes, HDAC6 inhibitors, and genetic modulation of KIF14 function. The results of this project will advance our understanding of the pathology of BBS and ciliopathies in general, and identify potential therapeutic opportunities for the treatments of these disorders.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10601 - Cell biology
OECD FORD - secondary branch
10605 - Developmental biology
OECD FORD - another secondary branch
30304 - Public and environmental health
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
DN - Environmental impact on health<br>EA - Morphology and cytology<br>EB - Genetics and molecular biology<br>FM - Hygiene
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
May 6, 2026
Finance
Total approved costs
11,522 thou. CZK
Public financial support
11,522 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK