Mechanosensation in the Development and Healing of the Junctional Epithelium

Provider

Czech Science Foundation

Programme

—

Call for proposals

—

Main participants

Masarykova univerzita / Lékařská fakulta

Contest type

M2 - International cooperation

Contract ID

26-22684K

Project name in Czech

Mechanosensation in the Development and Healing of the Junctional Epithelium

Annotation in Czech

The Junctional Epithelium(JE) is a critical structure that separates the hostile environment of the oral cavity from the periodontium. Its malfunction leads to periodontitis, ultimately resulting in tooth loss. Mechanisms that activate the regenerative potential of the JE remain largely unknown. This collaborative project between Masaryk Uni (CZ) and Leipzig Uni (DE) aims to uncover the mechanosensory properties of the JE in the context of its development, mechanical loading, and inflammation. To achieve our goals, we will employ a comprehensive methodological approach, including metabolic labeling, targeted knockouts of PIEZO1/2, lineage tracing, spatial transcriptomics, and whole-mount 3D imaging. Ultimately, we will investigate the cellular and molecular mechanisms underlying de novo formation of JE around dental implants. This research will elucidate fundamental mechanisms of JE regeneration with relation to mechanosensation. Our findings may lead to the development of new therapeutic approaches in orthodontics, periodontal disease treatment or better dental implants integration.

R&D category

ZV - Basic research

OECD FORD - main branch

10605 - Developmental biology

OECD FORD - secondary branch

30105 - Physiology (including cytology)

OECD FORD - another secondary branch

30208 - Dentistry, oral surgery and medicine

CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

EB - Genetics and molecular biology<br>ED - Physiology<br>FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

Realization period - beginning

Jul 1, 2026

Realization period - end

Dec 31, 2029

Project status

Z - Beginning multi-year project

Latest support payment

—

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data delivery code

CEP26-GA0-GF-R

Data delivery date

Jul 27, 2026

Total approved costs

8,392 thou. CZK

Public financial support

8,390 thou. CZK

Other public sources

2 thou. CZK

Non public and foreign sources

0 thou. CZK