Asymmetric Organocatalysis as a Gateway to Inherently Chiral Compounds

Project name in Czech
Asymmetric Organocatalysis as a Gateway to Inherently Chiral Compounds
Annotation in Czech
Inherently chiral compounds, such as macrocyclic polyaromatics, serve as a versatile platform for applications, including enantioselective recognition agents, molecular switches, host-guest systems, drug/gene delivery platforms, molecular devices, and other smart materials. However, the potential of enantiopure inherently chiral compounds remains limited due to the challenges associated with their synthesis. The goal of this project is to advance asymmetric organocatalysis by developing new methodologies for synthesizing enantiomerically enriched inherently chiral molecules. The first part of the project focuses on constructing chiral pillar[5]arenes, [2]rotaxanes, and calix[4]arenes via catalysis with chiral N-heterocyclic carbenes. The second part explores Brønsted acid and Lewis base-catalyzed approaches, including desymmetric reductive amination and asymmetric esterification of calix[4]arenes at distinct rim positions, as well as asymmetric intramolecular cyclization leading to the formation of novel eight-membered saddle-shaped molecules.

R&D category
ZV - Basic research
OECD FORD - main branch
10401 - Organic chemistry
OECD FORD - secondary branch
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OECD FORD - another secondary branch
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CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
CC - Organic chemistry

Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
Apr 29, 2026

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