Interactions of Wnt and Ah receptor signaling in regulation of functions of liver cells
Project goals
Toxic compounds activating Ah receptor (AhR) present an important group of environmental polutants, which may have deleterious effects on both animal and human health. Analysis of signaling pathways affected by AhR enables to describe both the mechanismsbeing responsible for the toxic effects of these compounds and to contribute to understanding of the role of specific signaling modules in physiological and pathological processes. The proposed project will focuse on the analysis of interactions of AhRsignaling and the processes controlled by Wnt signaling, which plays a crucial role in development, as well as e.g. in carcinogenesis. We will study interactions of both signaling pathways at the cellular level in regulation of expression of modell target genes, expression and activity of biotransformation enzymes and the factors modulating cell proliferation/cell death in modle liver and colon cells. The project will bring a novel information about the importance of AhR - Wnt interactions in toxic effects of AhR ligands, tumor development and in regulation of liver physiological functions.
Keywords
Ah receptorWntbeta-kateninbuněčná proliferaceapoptózajaterní buňkykarcinogeneze
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
Standardní projekty 12 (SGA02009GA-ST)
Main participants
—
Contest type
VS - Public tender
Contract ID
524/09/1337
Alternative language
Project name in Czech
Interakce signálních drah Wnt a Ah receptoru v regulaci funkcí jaterních buněk
Annotation in Czech
Základním cílem projektu je charakterizace interakcí signálních drah Ah receptoru a Wnt, která by mohla hrát roli v negativních účincích toxických environmentálních polutantů. Vzájemné interakce těchto dvou drah budou studovány především s využitím definovaných buněčných modelů in vitro.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
ED - Physiology
CEP - secondary branch
DN - Environmental impact on health
CEP - another secondary branch
EB - Genetics and molecular biology
10603 - Genetics and heredity (medical genetics to be 3)
10604 - Reproductive biology (medical aspects to be 3)
10605 - Developmental biology
10608 - Biochemistry and molecular biology
10609 - Biochemical research methods
30101 - Human genetics
30105 - Physiology (including cytology)
30304 - Public and environmental health
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
The project was excellent, both in terms of expertise and in terms of disbursement of funds.
Solution timeline
Realization period - beginning
Jan 1, 2009
Realization period - end
Dec 31, 2011
Project status
U - Finished project
Latest support payment
Apr 16, 2011
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP12-GA0-GA-U/02:2
Data delivery date
May 2, 2016
Finance
Total approved costs
3,614 thou. CZK
Public financial support
3,614 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK
Basic information
Recognised costs
3 614 CZK thou.
Public support
3 614 CZK thou.
100%
Provider
Czech Science Foundation
CEP
ED - Physiology
Solution period
01. 01. 2009 - 31. 12. 2011