Oxime antidotes for reactivation of cholinesterases inhibited by highly poisonous organophosphates (REACT)
Public support
Provider
Czech Science Foundation
Programme
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Call for proposals
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Main participants
Univerzita Hradec Králové / Přírodovědecká fakulta
Contest type
M2 - International cooperation
Contract ID
26-20584K
Alternative language
Project name in Czech
Oxime antidotes for reactivation of cholinesterases inhibited by highly poisonous organophosphates (REACT)
Annotation in Czech
The highly toxic organophosphorus compounds were used during serious incidents in the last decade. These agents are causing life endangering intoxication that are usually treated by combination of antidotes, where only reactivators (oximes) are able to split organophosphates from cholinesterase active site and restore their physiologic activity. However, the standard oximes were found ineffective antidotes for such highly toxic organophosphorus compounds. For these reasons, the current research is based on searching for oximes with increased reactivation for the specific organophosphates. Thus, this project is focused on proof of concept of increased organophosphate reactivation and organism protection using double charged pyridinium oximes, which will be designed, prepared and thoroughly evaluated for these purposes.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
30107 - Medicinal chemistry
OECD FORD - secondary branch
30108 - Toxicology
OECD FORD - another secondary branch
30104 - Pharmacology and pharmacy
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
FP - Other medical fields<br>FR - Pharmacology and apothecary chemistry
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
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Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GF-R
Data delivery date
May 23, 2026
Finance
Total approved costs
7,251 thou. CZK
Public financial support
7,251 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK