Molecular mechanisms of protein sorting in sensory cilia
Public support
Provider
Czech Science Foundation
Programme
—
Call for proposals
SGA0202600003
Main participants
Biotechnologický ústav AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
26-22371M
Alternative language
Project name in Czech
Molecular mechanisms of protein sorting in sensory cilia
Annotation in Czech
Sensory cilia are antenna-like organelles of eukaryotic cells that detect stimuli and transmit signals, shaping gene expression and cell behaviour. Separated from the rest of the cell by a diffusion barrier, cilia have a distinct environment rich in membrane proteins and signalling enzymes. This heterogeneity is maintained by intraflagellar transport (IFT), which is essential for the entry, exit, and distribution of ciliary proteins, with disruptions leading to ciliopathies. The mechanisms by which IFT regulates protein entry and exit to maintain ciliary compartmentalization, as well as how disruptions in protein composition arise during ciliopathies or environmental changes, remain unclear. In my research, we will develop novel single-molecule fluorescence microscopy tools to resolve intracellular dynamics in sensory cilia of living C. elegans to address key gaps in the field. We will decipher how IFT preserves and regulates the diverse protein composition and distribution within cilia of living C. elegans, vital for sensory function at both cellular and organismal level.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10601 - Cell biology
OECD FORD - secondary branch
10610 - Biophysics
OECD FORD - another secondary branch
10608 - Biochemistry and molecular biology
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
BO - Biophysics<br>CE - Biochemistry<br>EA - Morphology and cytology<br>EB - Genetics and molecular biology
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2030
Project status
Z - Beginning multi-year project
Latest support payment
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Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GM-R
Data delivery date
Apr 27, 2026
Finance
Total approved costs
24,956 thou. CZK
Public financial support
24,956 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK