Anti-inflammatory activity of plant quinones
Project goals
Scope of this project is the study inhibition of cyclooxygenases (COXs) and lipoxygenases (LOXs) enzymes by plant quinones. COXs and LOXs play key role in regulation of inflammatory diseases, in growth of cancer cells and in other pathological processesin mammalian tissues. Therefore currant research is aimed on searching for dual inhibitors of COX-2 and 5-LOX enzymes. Plant compounds are served as prospective source of these compounds. In vitro enzyme assay monitoring production of prostaglandins andleukotrienes which are products of COX and LOX pathway respectively will be used for tests. Screening of selected plant quinones for COX-1, COX-2 and 5-LOX inhibition and impact of simple derivatization steps on its activity will be carried out during the project solving. For perspective compounds inhibitory concentrations (IC50) will established and selectivity for enzymes will be calculated. Most active compounds will be tested for its toxicity. Moreover, study of mechanism of inhibition will be performed for selected constituents.
Keywords
Public support
Provider
Czech Science Foundation
Programme
Post-graduate (doctorate) grants
Call for proposals
Postdoktorandské granty 9 (SGA02009GA1PD)
Main participants
—
Contest type
VS - Public tender
Contract ID
525/09/P528
Alternative language
Project name in Czech
Protizánětlivá aktivita rostlinných chinonů
Annotation in Czech
Cílem projektu je nalezení látek efektivně inhibujících současně COX-2 a 5-LOX, které by mohly sloužit pro vývoj nových bezpečných protizánětlivých léků. Dalším cílem je ověřit vliv jednoduchých derivatizací chinonů na jejich inhibiční aktivitu. U aktivních látek zjištění způsobu inhibice enzymů.
Scientific branches
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
The project gone according to plan both in terms of expertise and in terms of disbursement of funds.
Solution timeline
Realization period - beginning
Jan 1, 2009
Realization period - end
Dec 31, 2011
Project status
U - Finished project
Latest support payment
Apr 16, 2011
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP12-GA0-GP-U/03:3
Data delivery date
May 2, 2016
Finance
Total approved costs
1,219 thou. CZK
Public financial support
1,219 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK
Basic information
Recognised costs
1 219 CZK thou.
Public support
1 219 CZK thou.
100%
Provider
Czech Science Foundation
CEP
GM - Food industry
Solution period
01. 01. 2009 - 31. 12. 2011