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LD13037

Transport of cations and protons across biomembranes - molecular structure and activity mechanism of Na+/H+ antiporters from lower eukaryots II

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    COST CZ

  • Call for proposals

    COST CZ 3 (SMSM2013LD3)

  • Main participants

  • Contest type

    VS - Public tender

  • Contract ID

    MSMT-9339/2013-311

Alternative language

  • Project name in Czech

    Transport kationtů a protonů přes buněčné membrány - molekulární struktura a mechanismus aktivity Na+/H+ antiporterů nižších eukaryot II

  • Annotation in Czech

    Objasnění fungování antiporterů kationtů alkalických kovů v kvasinkách a stanovení jejich úlohy v udržování homeostáze kationtů a pHH v konvenčních a nekonvenčních kvasinkových druzích.

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    EB - Genetics and molecular biology

  • CEP - secondary branch

    EE - Microbiology, virology

  • CEP - another secondary branch

    CE - Biochemistry

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10606 - Microbiology<br>10607 - Virology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    A structural model of yest plasma-membrane antiporter has been constructed and amino-acid residues crucial for the activity and substrate specificity identified, based on contamination of site-directed mutagenesis, heterologous expression, tolerance phenotypes and measurements of cation content.

Solution timeline

  • Realization period - beginning

    Jan 1, 2013

  • Realization period - end

    Nov 30, 2013

  • Project status

    U - Finished project

  • Latest support payment

    Feb 25, 2013

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP14-MSM-LD-U/01:1

  • Data delivery date

    Jun 30, 2014

Finance

  • Total approved costs

    753 thou. CZK

  • Public financial support

    401 thou. CZK

  • Other public sources

    352 thou. CZK

  • Non public and foreign sources

    0 thou. CZK