Role of the oxygen radical stress in hypoxic pulmonary hypertension
Public support
Provider
Ministry of Education, Youth and Sports
Programme
COST CZ
Call for proposals
COST CZ 4 (SMSM2014LD4)
Main participants
Univerzita Karlova / 2. lékařská fakulta
Contest type
VS - Public tender
Contract ID
MSMT-8634/2014-1
Alternative language
Project name in Czech
Role radikálového stresu při hypoxické plicní hypertenzi
Annotation in Czech
Rozšíření znalostí o mechanismech produkce ROS při vystavení dlouhodobému nedostaku kyslíku a účinku ROS na plicní cévy. možmost terapeutického ovlivnění tohoto procesu.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
FA - Cardiovascular diseases including cardio-surgery
CEP - secondary branch
—
CEP - another secondary branch
—
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
30201 - Cardiac and Cardiovascular systems
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
"1. We conclude that maternal diabetes in rat model increases fetoplacental vascular resistance to a similar extent as chronic hypoxia, that these two stimuli are not additive and that changes in vascular tone are not responsible. 2. Increased superoxide production of alveolar macrophages (AM) in hypoxia may result from attenuated suppression of AM by hypoxia induced changes in their environment "
Solution timeline
Realization period - beginning
Apr 1, 2014
Realization period - end
Nov 30, 2016
Project status
U - Finished project
Latest support payment
Feb 12, 2016
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP17-MSM-LD-U/01:1
Data delivery date
Jun 23, 2017
Finance
Total approved costs
2,511 thou. CZK
Public financial support
2,085 thou. CZK
Other public sources
426 thou. CZK
Non public and foreign sources
0 thou. CZK