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LD14068

Role of the oxygen radical stress in hypoxic pulmonary hypertension

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    COST CZ

  • Call for proposals

    COST CZ 4 (SMSM2014LD4)

  • Main participants

    Univerzita Karlova / 2. lékařská fakulta

  • Contest type

    VS - Public tender

  • Contract ID

    MSMT-8634/2014-1

Alternative language

  • Project name in Czech

    Role radikálového stresu při hypoxické plicní hypertenzi

  • Annotation in Czech

    Rozšíření znalostí o mechanismech produkce ROS při vystavení dlouhodobému nedostaku kyslíku a účinku ROS na plicní cévy. možmost terapeutického ovlivnění tohoto procesu.

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    FA - Cardiovascular diseases including cardio-surgery

  • CEP - secondary branch

  • CEP - another secondary branch

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    30201 - Cardiac and Cardiovascular systems

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    "1. We conclude that maternal diabetes in rat model increases fetoplacental vascular resistance to a similar extent as chronic hypoxia, that these two stimuli are not additive and that changes in vascular tone are not responsible. 2. Increased superoxide production of alveolar macrophages (AM) in hypoxia may result from attenuated suppression of AM by hypoxia induced changes in their environment "

Solution timeline

  • Realization period - beginning

    Apr 1, 2014

  • Realization period - end

    Nov 30, 2016

  • Project status

    U - Finished project

  • Latest support payment

    Feb 12, 2016

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP17-MSM-LD-U/01:1

  • Data delivery date

    Jun 23, 2017

Finance

  • Total approved costs

    2,511 thou. CZK

  • Public financial support

    2,085 thou. CZK

  • Other public sources

    426 thou. CZK

  • Non public and foreign sources

    0 thou. CZK