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LD15099

Comparative study of Huntingtons disease: bioenergetics functions of mitochondria in patients and in transgenic minipigs

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    COST CZ

  • Call for proposals

    COST CZ 5 (SMSM2015LD5)

  • Main participants

    Univerzita Karlova / 1. lékařská fakulta

  • Contest type

    VS - Public tender

  • Contract ID

    MSMT-33315/2015-1

Alternative language

  • Project name in Czech

    Srovnávací studie u Huntingtonovy nemoci: bioenrgetická funkce mitochondrií u pacientů a u transgenního miniprasete

  • Annotation in Czech

    1 ) Studovat dopad HD na mitochondriální energetický metabolismus v buňkách periferních tkání u pacientů s Huntingtonovou nemocí; 2) Charakterizovat dopad HD na mitochondriální energetický metabolismus v buňkách periferních tkání u modelu miniprasete transgenního pro N-terminální část lidského mutovaného huntingtinu

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    CE - Biochemistry

  • CEP - secondary branch

    ED - Physiology

  • CEP - another secondary branch

    EB - Genetics and molecular biology

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10603 - Genetics and heredity (medical genetics to be 3)<br>10604 - Reproductive biology (medical aspects to be 3)<br>10605 - Developmental biology<br>10608 - Biochemistry and molecular biology<br>10609 - Biochemical research methods<br>30101 - Human genetics<br>30105 - Physiology (including cytology)

Completed project evaluation

  • Provider evaluation

    V - Vynikající výsledky projektu (s mezinárodním významem atd.)

  • Project results evaluation

    Selected proteins of mitochondrial energetic metabolism were analyzed in cultivated skin fibroblasts, isolated lymphocytes and buccal epithelial cells from patients with Huntington's disease (HD) and TgHD minipigs. The results are indicative for reduced mitochondrial function in peripheral blood lymphocytes in patients with fully manifested HD. Affected proteins can serve as suitable biomarkers for HD development. The results were published.

Solution timeline

  • Realization period - beginning

    Oct 14, 2015

  • Realization period - end

    Dec 31, 2017

  • Project status

    U - Finished project

  • Latest support payment

    Feb 24, 2017

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP18-MSM-LD-U

  • Data delivery date

    Oct 26, 2022

Finance

  • Total approved costs

    1,522 thou. CZK

  • Public financial support

    1,522 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK