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LL2315

Regulation of adaptive immune response by intestinal epithelial cells

Project goals

Implementation of a frontier research project in the field of immunology, the subfield of host-pathogen interaction with a focus on the ability of intestinal epithelial cells to modulate the adaptive immune response through antigen presentation. The main objective of the project is to decipher the mechanisms used by the intestinal epithelium to influence the adaptive immune response and to reciprocally investigate the impact of adaptive immunity on the intestinal epithelium.

Keywords

rregulation of the immune responseantigen presentationantigen presenting cellsimmune response to bacteria

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

    ERC CZ

  • Call for proposals

    SMSM2023LL001

  • Main participants

    Univerzita Karlova / Přírodovědecká fakulta

  • Contest type

    VS - Public tender

  • Contract ID

    MSMT-2853/2023

Alternative language

  • Project name in Czech

    Regulace adaptivní imunitní odpovědi střevními epiteliálními buňkami

  • Annotation in Czech

    Realizace projektu hraničního výzkumu v oblasti imunologie v podoblasti interakce hostitele s patogenem se zaměřením na schopnost modulace adaptivní imunitní odpovědi pomocí antigenní prezentace zprostředkované střevními epiteliálními buňkami. Hlavním cílem projektu je rozklíčovat mechanismy využívané střevním epitelem k ovlivnění adaptivní imunitní odpovědi a zároveň zkoumat vliv adaptivní imunity na střevní epitel.

Scientific branches

  • R&D category

    ZV - Basic research

  • OECD FORD - main branch

    30102 - Immunology

  • OECD FORD - secondary branch

    —

  • OECD FORD - another secondary branch

    —

  • EC - Immunology

Solution timeline

  • Realization period - beginning

    Sep 1, 2023

  • Realization period - end

    Dec 31, 2025

  • Project status

    K - Ending multi-year project

  • Latest support payment

    Jan 11, 2024

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP25-MSM-LL-R

  • Data delivery date

    Feb 20, 2025

Finance

  • Total approved costs

    17,578 thou. CZK

  • Public financial support

    17,578 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK

Basic information

Recognised costs

17 578 CZK thou.

Public support

17 578 CZK thou.

100%

Provider

Ministry of Education, Youth and Sports

OECD FORD

Immunology

Solution period

01. 09. 2023 - 31. 12. 2025

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