The role of ATF2 transcription factor in development and homeostasis of colon and its involvement in progression of colorectal carcinoma
Project goals
1) Characterisation of lethal phenotype in ATF2 KO mouse model 2) Mapping of ATF2 expression during development and in adult tissues 3) Distinguishing tissue specific roles (Inducible Knock out startegy) 4) Molecular context of ATF2 in intestine development, homeostasis and cancer 5) Metabolomic fingerprint of ATF2 mutation
Keywords
Atf2ColonEmbryonic gutIntestine homeostasisColorectal carcinoma
Public support
Provider
Ministry of Education, Youth and Sports
Programme
INTER-EXCELLENCE
Call for proposals
SMSM2019LTAB1
Main participants
Ústav molekulární genetiky AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
MSMT-10249/2019-2
Alternative language
Project name in Czech
Role transkripčního faktoru ATF2 při vývoji a homeostázi tlustého střeva a jeho zapojení do vývoje kolorektálního karcinomu
Annotation in Czech
1) Charakterizace letálního fenotypu na myším modelu Atf2 KO 2) Mapování exprese Atf2 během vývoje a v dospělých tkáních 3) Identifikace tkáňově specifické role Atf2 (Startegie Inducibilních Knock out) 4) Molekulární kontext ATF2 ve vývoji střev, homeostázy a kolorektálního karcinomu 5) Metabolomický fingerprint mutace v Atf2
Scientific branches
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
During embryonic development, the developing intestine is folded into precisely regulated loops, which are then permanent throughout life and are essential for proper physiological function of the intestine. The transcription factor Atf2 directly affects the emerging smooth muscle cells in the mesentery and thus directly affects how the emerging intestinal loops will be stored in the abdominal cavity by affecting the contractility of mesentery. The outputs of the project in the form of scientific publications will expand current knowledge about the function of Atf2 during development and during pathological processes. In the long term, this research can contribute to improving the health of the population, where the incidence of colorectal cancer in particular is significantly represented in the Czech Republic.
Solution timeline
Realization period - beginning
Jul 1, 2019
Realization period - end
Dec 31, 2021
Project status
U - Finished project
Latest support payment
Sep 5, 2020
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP22-MSM-LT-U
Data delivery date
Jun 30, 2022
Finance
Total approved costs
1,200 thou. CZK
Public financial support
1,200 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK
Recognised costs
1 200 CZK thou.
Public support
1 200 CZK thou.
0%
Provider
Ministry of Education, Youth and Sports
OECD FORD
Genetics and heredity (medical genetics to be 3)
Solution period
01. 07. 2019 - 31. 12. 2021