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Projects

647 projects (0,103s) •

Project

Functional study of the Na+, K+/H+antiporter Cnh1p in the pathogenic yeast Candida albicans (KJB5011307)

results should bring new knowledge about the regulation of K+ and pH homeostasis in CIntracellular pH and K+ content belong among factors controlling morphology with substrate specificity for four alkalimetal cations (Na+,...

EB - Genetika a molekulární biologie

  • 2003 - 2004
    • •
  • 597 tis. Kč
    • •
  • 329 tis. Kč
    • •
  • AV ČR
Project

Physiological role of cation/proton antiporters in monovalent cation homeostasis, Ca2+ signalling and intracellular pH regulation (GA17-01953S)

transporters. If the activity of ion transporters and consequently ion homeostasis with the aim of (i) determining new structural and functional elements in a group of Na+(K cation-homeostasis regulatory network in the uni...

EE - Mikrobiologie, virologie

  • 2017 - 2019
    • •
  • 5 032 tis. Kč
    • •
  • 4 762 tis. Kč
    • •
  • GA ČR
Project

Age-related changes in the structure and function of astrocytes (GA305/08/1384)

We hypothesise that astrogliosis triggers functional changes that impair homeostasis in aged brain. We will exploit a transgenic mouse with intrinsically fluorescent astrocytes that enables the unequivocal identification of these cells relat...

FH - Neurologie, neurochirurgie, neurovědy

  • 2008 - 2009
    • •
  • 2 530 tis. Kč
    • •
  • 2 530 tis. Kč
    • •
  • GA ČR
Project

Transport systems involved in intracellular pH homeostasis and yeast tolerance to low external pH (LTC20006)

and pH homeostasis in yeast cells. Further, new knowledge will help to identify transporters whose engineering may improve the robustness of intracellular pH homeostasis......

Microbiology

  • 2020 - 2023
    • •
  • 4 326 tis. Kč
    • •
  • 4 326 tis. Kč
    • •
  • MŠMT
Project

Intracellular pH and alkali-metal-cation homeostasis in Candida virulence and pathogenicity (GAP302/12/1151)

that includes an efficient regulation of intracellular K+ and pH homeostases. These two will be characterized in detail with the aim to understand the role of K+ import and export systems in the maintenance of potassium homeost...

EE - Mikrobiologie, virologie

  • 2012 - 2015
    • •
  • 5 402 tis. Kč
    • •
  • 5 402 tis. Kč
    • •
  • GA ČR
Project

Role of Na/H antiporters in cell physiology - transporters teamwork in intracellular pH and K+ homeostasis (IAA500110801)

Na+/H+ antiporters serve in all organisms mainly to maintain intracellular homeostasis of alkali metal cations and pH. In the model yeast Saccharomyces cerevisiae, three members of the family exist: Nha1p is in the plasma membrane, Kha1 in t...

EB - Genetika a molekulární biologie

  • 2008 - 2012
    • •
  • 4 020 tis. Kč
    • •
  • 4 020 tis. Kč
    • •
  • AV ČR
Project

Alkali-metal-cation homeostasis in Saccharomyces cerevisiae biology (GA204/08/0354)

To maintain the homeostasis of intracellular pH and alkali-metal-cation concentration (stable and high K+/Na+ ratio) yeast S. cerevisiae employs more than 10 plasma-membrane and organelle-membrane transporters. Though their individu...

EE - Mikrobiologie, virologie

  • 2008 - 2010
    • •
  • 3 102 tis. Kč
    • •
  • 3 102 tis. Kč
    • •
  • GA ČR
Project

Eukaryotic Na+/H+ antiporters – key elements in their structure determining activity, biogenesis and physiological functions (GA21-08985S)

All biological processes depend on pH homeostasis and ion concentrations. Na+/H+ antiporters are cation transport systems that participate in ensuring the optimal intracellular level of alkali-metal cations (Na+, K+) and H+ (pH) in ...

Biochemistry and molecular biology

  • 2021 - 2024
    • •
  • 5 956 tis. Kč
    • •
  • 5 956 tis. Kč
    • •
  • GA ČR
Project

Telomere homeostasis as potential biomarker of risk, prognosis and progression in gynaecologic tumours. (NU21-03-00145)

Disruption of telomere length (TL) homeostasis in lymphocytes has been at the determination of the telomere homeostasis dynamic in onset and progression of gynaecological in the patients than in healthy subjects. It seems that TL

Oncology

  • 2021 - 2024
    • •
  • 10 389 tis. Kč
    • •
  • 10 389 tis. Kč
    • •
  • MZ
Project

The role of ATF2 transcription factor in development and homeostasis of colon and its involvement in progression of colorectal carcinoma (LTAB19002)

1) Characterisation of lethal phenotype in ATF2 KO mouse model 2) Mapping of ATF2 expression during development and in adult tissues 3) Distinguishing tissue specific roles (Inducible Knock out startegy) 4) Molecular context of ATF2 in intestine d...

Genetics and heredity (medical genetics to be 3)

  • 2019 - 2021
    • •
  • 1 200 tis. Kč
    • •
  • 1 200 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 647