Dynamics of telomeres and rDNA loci in plant cell nuclei
Public support
Provider
Ministry of Education, Youth and Sports
Programme
INTER-EXCELLENCE
Call for proposals
SMSM2020LTC01
Main participants
Masarykova univerzita / Středoevropský technologický institut
Contest type
VS - Public tender
Contract ID
MSMT-21080/2020-3
Alternative language
Project name in Czech
Dynamics of telomeres and rDNA loci in plant cell nuclei
Annotation in Czech
The cell nucleus and its detailed structure has always represented an exciting cellular compartment and stimulated establishment of the new research areas and innovative methodologies. Plants represent important model systems with a high developmental plasticity and variable organization of their genomes, differing, e.g., in the genome size, proportion of repetitive elements or the chromosome numbers. Our research group integrates studies in the field of telomere biology, chromatin structure, DNA repair and epigenetics. Rapid progress of the cell biology occurred in line with the development of super-resolution microscopy approaches and advanced assays to investigate chromatin organization, allowing a detailed insight into the spatial organization of individual nuclear subdomains and other functional elements, such as nucleolus, telomeres or clusters of ribosomal rRNA genes. In the proposed project, we will investigate the effect of molecular and environmental factors on telomere composition and telomerase regulation and decipher functional links between chromatin assembly and epigenetic memory in the telomere maintenance, representing a good measure of overall genome stability.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10611 - Plant sciences, botany
OECD FORD - secondary branch
—
OECD FORD - another secondary branch
—
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
EF - Botany
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
The solution brought results in the field of factors affecting the stability of the genome, namely rDNA and telomeres. It was determined how environmental factors, especially the levels of cadmium and sulfates in the soil, influence the growth and development of plants. New methods using advanced microscopic approaches have been developed. Results were published in 9 articles in journals of the WOS database, including the highly prestigious J. Hazard. Mat., New Phytol., and Plant Physiol.
Solution timeline
Realization period - beginning
Jun 1, 2020
Realization period - end
Apr 30, 2023
Project status
U - Finished project
Latest support payment
Feb 17, 2023
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP24-MSM-LT-U
Data delivery date
Jul 1, 2024
Finance
Total approved costs
4,069 thou. CZK
Public financial support
4,069 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK