Role of adhesion-GPCRs during viral infection of mammalian cells
Public support
Provider
Ministry of Education, Youth and Sports
Programme
INTER-EXCELLENCE
Call for proposals
SMSM2020LTC01
Main participants
Ústav organické chemie a biochemie AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
MSMT-21080/2020-32
Alternative language
Project name in Czech
Role of adhesion-GPCRs during viral infection of mammalian cells
Annotation in Czech
Cíle projektu zahrnují: - analyzovat změny v expresi aGPCR a / nebo proteinů zapojených do aGPCR drah mezi infikovanými a neinfikovanými buňkami pomocí hmotnostní spektrometrie -vyhodnotit účinek vybraných aGPCR a / nebo proteinů zapojených do aGPCR drah na replikaci viru - Identifikovat a charakterizovat virové proteiny interagující s aGPCR a / nebo proteiny zapojenými do aGPCR drah.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10607 - Virology
OECD FORD - secondary branch
10608 - Biochemistry and molecular biology
OECD FORD - another secondary branch
—
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
CE - Biochemistry<br>EB - Genetics and molecular biology<br>EE - Microbiology, virology
Completed project evaluation
Provider evaluation
V - Vynikající výsledky projektu (s mezinárodním významem atd.)
Project results evaluation
We determined upregulated expression of two adhesion GPCRs in lung cells during SARS-CoV-2 infection. After downregulation of their endogenous levels in lung cells we observed reduction in SARS-CoV-2 replication and infectivity. Thereby we accomplished main goal of our project to show that aGPCRs may have a role during viral infections.
Solution timeline
Realization period - beginning
Jun 1, 2020
Realization period - end
Oct 31, 2023
Project status
U - Finished project
Latest support payment
Feb 17, 2023
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP24-MSM-LT-U
Data delivery date
Jul 1, 2024
Finance
Total approved costs
5,951 thou. CZK
Public financial support
4,752 thou. CZK
Other public sources
1,199 thou. CZK
Non public and foreign sources
0 thou. CZK